The Evaluation of the Effect of Microfluidic Sperm Sorting Chip 'Labs-on-a-chip' on IVF Success in Male Factor

Conditions:   Male Infertility;   Infertility, Male Interventions:   Other: MicroFluidic Sperm Sorting Chips;   Other: Gradient-Density Centrifugation Sponsors:   Bezmialem Vakif University;   Yeditepe University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China. PMID: 31198195 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionWhile components of a mixture of lipids and lipophilic micronutrients were associated with live birth outcomes following IVF, a larger investigation is necessary to fully evaluate the potential clinical implications.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Authors: Mencaglia L, Cerboneschi M, Ciociola F, Ricci S, Mancioppi I, Ambrosino V, Ferrandi C, Strozzi F, Piffanelli P, Grasselli A Abstract Female fertility plays a decisive role in the reproduction of mammals, with related issues that include oocyte or embryo quality, establishment of pregnancy, and the physiology of the tissues that contribute to reproduction and metabolic disorders associated with reproductive failure. Although reproductive failure may be attributed to various factors in different species, female infertility is largely controlled by a number of molecular signals that can be regulated in a cycl...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
In Britain, children of infertile couples who have used a sperm or egg donor will soon be able to find out the name and recent address of the donor.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
AbstractPurpose of ReviewThe classification of morphologically normal sperm has been progressively redefined. Concurrently, our understanding of the significance of sperm morphology in relation to male factor infertility has evolved. In this review, we will discuss the evolution of sperm morphology assessment and factors that contribute to its measurement variability. We will examine the impact of sperm morphology on natural pregnancy, IUI, IVF, and ICSI outcomes.Recent FindingsThere is a lack of consensus on sperm morphology classification, technique, and inter-observer grading variability. Current evidence suggests sperm...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
Derin Gebhardt, 37, from Roundup, Montana, was diagnosed in May 2017 with a pituitary tumor, which was causing a decrease in normal levels of sex hormones and behind his infertility.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 13 June 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Leila Kohan, Omid Tabiee, Neda SepahiAbstractObjectiveMale infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Spermatogenic failure accounts for more than half of male infertility cases. Heat shock proteins (HSPs) are the molecular chaperones that are involved in different developmental stages of spermatogenesis. The current study was planned to investigate the role of HSPA1L rs2227956 and HSPA1B rs1061581 gene polymorphis...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Authors: Campo-Engelstein L, Chen D, Baratz AB, Johnson EK, Finlayson C Abstract Fertility preservation has become more common for various populations, including oncology patients, transgender individuals, and women who are concerned about age-related infertility. Little attention has been paid to fertility preservation for patients with differences/disorders of sex development (DSD). Our goal in this article is to address specific ethical considerations that are unique to this patient population. To this end, we present a hypothetical DSD case. We then explore ethical considerations related to patient's age, risk ...
Source: Journal of Clinical Ethics - Category: Medical Ethics Tags: J Clin Ethics Source Type: research
Abstract Enhancer of zeste homolog 2 (EZH2) is a rate-limiting catalytic subunit of a histone methyltransferase, polycomb repressive complex, which silences gene activity through the repressive histone mark H3K27me3. EZH2 is critical for epigenetic effects of early estrogen treatment, and may be involved in uterine development and pathologies. We investigated EZH2 expression, regulation and its role in uterine development/function. Uterine epithelial EZH2 expression was associated with proliferation and was high neonatally then declined by weaning. Pre-weaning uterine EZH2 expression was comparable in wild-type an...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
Ikawa M Abstract More than 1,000 genes are predicted to be predominantly expressed in mouse testis, yet many of them remain unstudied in terms of their roles in spermatogenesis and sperm function and their essentiality in male reproduction. Since individually indispensable factors can provide important implications for the diagnosis of genetically-related idiopathic male infertility and may serve as candidate targets for the development of non-hormonal male contraceptives, our laboratories continuously analyze the functions of testis-enriched genes in vivo by generating knockout mouse lines using the CRISPR/Cas9 s...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
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