Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis

Conditions:   Cystic Fibrosis;   Cystic Fibrosis-related Diabetes;   Cystic Fibrosis Liver Disease;   Pancreatic Steatosis;   Hepatic Steatosis Interventions:   Device: Frequently Sampled Oral Glucose Tolerance Test and CGM;   Radiation: MRI Pancreas and Liver Sponsor:   University Hospitals Cleveland Medical Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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PMID: 31567247 [PubMed - in process]
Source: The American Journal of Nursing - Category: Nursing Authors: Tags: Am J Nurs Source Type: research
Liraglutide (Victoza) is now approved for use in children 10 years and older with type 2 diabetes.Tezacaftor–ivacaftor (Symdeko) is now approved for children six years and older with cystic fibrosis and a specific genetic mutation. Previously, the combination drug was approved for children ages 12 and older.The combination antiinfective ceftolozane–tazobactam (Zerbaxa) is now approved to treat hospital-acquired and ventilator-associated bacterial pneumonia in patients 18 years and older. The dose of ceftolozane–tazobactam is higher for this indication than for others.
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
Conclusion: Good2Go is a valid 20-item questionnaire to assess transition readiness in adolescents with chronic conditions and may be useful in routine care to propose individually tailored preparation for their transfer to adult healthcare. Further research is now needed to analyze correlation between domain scores and success of transition.What is Known:•In adolescents with chronic conditions, the use of transition readiness questionnaires is recommended to propose individually tailored preparation for their transfer to adult healthcare.•However, no French-language questionnaire has been so far validated.What i...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Abstract Historically, the practice of medicine has been a physically intimate endeavor. Physicians have used their hands to palpate and reveal the secrets hidden within the body. Smelling the breath for the ketosis of diabetes or tasting the skin for the saltiness of cystic fibrosis were among the physician's essential practices. Today, perhaps the most defining characteristic of a brilliant clinician is the ability to synthesize many images-from electrocardiograms, ultrasounds, CT scans, and so forth-into a coherent picture that can guide our diagnosis and treatment. Yet this is rapidly becoming a Sisyphean task...
Source: The Hastings Center Report - Category: Medical Ethics Authors: Tags: Hastings Cent Rep Source Type: research
In this study we compared BMI, height, weight, IGF-I, GHBP and GHR gene expression values (evaluated by Chemiluminescent Immunometric assay; ELISA and Real time PCR respectively) in CF patients diagnosed through NBS (New born screening), or by symptoms (Late Diagnosis (LD)) and in healthy controls. RESULTS: BMI increased significantly in patients between the time of diagnosis and check-ups (p
Source: Clinical Medicine and Research - Category: General Medicine Authors: Tags: Clin Med Res Source Type: research
BackgroundThere is a paucity of data evaluating antibiotic use in anterior skull ‐base surgery (ASBS). The goal of this study was to determine antibiotic prescribing patterns and factors that influence antibiotic use in ASBS.MethodsAn online ‐based survey was distributed to the membership of the North American Skull Base Society in 2018. Outcomes included practitioner preference regarding intraoperative and postoperative antibiotic use, practice location and environment, surgeon experience, and patient factors influencing antibiotic u se.ResultsThere were 208 respondents (25.6% response rate) of which 182 (87.5%) perfo...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study uses CF Foundation Patient Registry to examine the impact of screening practices at centers across the United States from 2008 to 2015. We examined the association of screening practices and CFRD diagnosis at individual centers and trends in ppFEV1 and BMI percentile prior t o and after diagnosis.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Cystic fibrosis-related diabetes (CFRD) is the most common extrapulmonary manifestation of cystic fibrosis. The current standard of care for CFRD involves treatment with insulin, typically via multiple daily injections. We conducted a small pilot study comparing usual care with automated glycemic control using the bihormonal (insulin and glucagon) and insulin-only configurations of the bionic pancreas. Both configurations of the bionic pancreas achieved good glycemic control, with mean glucose levels
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research
Abstract PURPOSE: Results of a study to determine whether obesity is associated with acute kidney injury (AKI) among patients receiving combination therapy with piperacillin-tazobactam and vancomycin are reported. METHODS: A retrospective, single-center cohort study of patients who received combination therapy for at least 48 hours was conducted using data from the University of Kentucky Center for Clinical and Translational Science's Enterprise Data Trust. Patients with chronic kidney disease, baseline creatinine clearance of less than 30 mL/min, cystic fibrosis, or missing height or weight information were ...
Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Tags: Am J Health Syst Pharm Source Type: research
Dysfunction of the pancreas is related to a number of diseases, most famously diabetes. Conditions such as cystic fibrosis-related diabetes (CFRD), are particularly difficult to study in a laboratory setting, but researchers at Cincinnati Children&rs...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials Medicine Source Type: blogs
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