Determination of a Dose of Moxidectin in Individuals < 12 Years of Age

Condition:   Onchocerciasis Intervention:   Drug: Moxidectin Sponsor:   Medicines Development Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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by Ferdinand Ngale Njume, Stephen Mbigha Ghogomu, Robert Adamu Shey, Lea Olive Tchouate Gainkam, Philippe Poelvoorde, Perrine Humblet, Joseph Kamgno, Annie Robert, Leon Mutesa, Christophe Lelubre, Evelina Edelweiss, Arnaud Poterszman, Susi Anheuser, Luc Vanhamme, Jacob SouopguiOnchocerca volvulus is the nematode pathogen responsible for human onchocerciasis also known as “River blindness”, a neglected tropical disease that affects up to 18 million people worldwide. Helminths Excretory Secretory Products (ESPs) constitute a rich repertoire of molecules that can be exploited for host-parasite relationship, diagno...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Robert Colebunders, Joseph Nelson Siewe Fodjo, Adrian Hopkins, An Hotterbeekx, Thomson L. Lakwo, Akili Kalinga, Makoy Yibi Logora, Maria-Gloria Bas áñez
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Joseph Nelson Siewe Fodjo, Michel Mandro, Deby Mukendi, Floribert Tepage, Sonia Menon, Swabra Nakato, Fran çoise Nyisi, Germain Abhafule, Deogratias Wonya’rossi, Aimé Anyolito, Richard Lokonda, An Hotterbeekx, Robert Colebunders BackgroundHigh epilepsy prevalence and incidence were observed in onchocerciasis-endemic villages in the Democratic Republic of Congo (DRC). We investigated the clinical characteristics of onchocerciasis-associated epilepsy (OAE), and the relationship between seizure severity and microfilarial density. MethodsIn October 2017, ivermectin-naive persons with epilepsy (PWE) were ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Conclusions/SignificanceThese results suggest that the optimized EWT might be capable of reducing local vector black fly biting in areas commonly frequented by residents. Together with other recently developed methods of community directed vector control, the traps may augment ivermectin MDA, bringing the goal of onchocerciasis elimination within reach in much of Africa.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
AbstractIn a recent article we discussed the feasibility of onchocerciasis elimination in Africa by 2025. We expressed concern that elimination may be impeded by failure to build on the lessons learned in the African onchocerciasis control programmes and the introduction of strategies and tools from the Americas. Richards et al. and Cupp et al. wrote to refute our concern and described recent achievements with stopping treatment in some areas.In this response, we discuss their arguments which did not convince us. We point out several scientific flaws in the American conceptual framework of elimination which has led to long...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
AbstractA recent article “Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes” inInfectious Diseases of Poverty claimed that undue influence on African programs by concepts developed by the Onchocerciasis Elimination Program of the Americas (OEPA) is detrimental to stopping mass drug administration (MDA) in Africa. This claim is made despite a record year for MDA stoppage in four African countries of>  3.5 million treatments in 2018, far exceeding any past OEPA or African Program for Onchocerciasis Control (APOC) stop MDA success.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
ConclusionsProgrammatic treatment and evaluation approaches, pioneered in the Americas, are the most efficient among the existing tools for elimination, and their broader use could catalyze the successful elimination of this disease in Africa.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
ConclusionsNational programs need to regularly monitor and evaluate the performance and progress of their interventions, while envisaging the complete elimination of onchocerciasis from their territory. Factors hindering the targeted goal of interruption of parasite transmission need to be identified and remedial actions should be taken. If possible and appropriate, ATSs need to be implemented to accelerate disease elimination by 2025.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
AbstractPurpose of reviewTo present ivermectin as a transformational tool for the control of neglected tropical diseases (NTDs) such as onchocerciasis and the drug of choice for the treatment of strongyloidiasis. Ivermectin is being re-discovered as a candidate drug for a variety of new indications among NTDs. In this review, new data are analyzed and put in context of current research interest as well as of the un-addressed issues for the treatment of soil-transmitted helminths (STH) infections.Recent findingsThe addition of ivermectin to the benzimidazole drugs appears as the most promising solution for three key issues ...
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research
Conclusions and recommendationsTrust must be built up gradually through transparency and by de-politicising interventions. This can be done by engaging the community at regular intervals during research and data collection and the dissemination of results in addition to involvement during service delivery for prevention and treatment. Maintaining a regular feedback loop with the community will help control rumours, build trust, and improve the preparations for adequate dissemination.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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