Multimorbidity in people living with dementia

Publication date: Available online 22 May 2019Source: Case Reports in Women's HealthAuthor(s): Tomas James Welsh
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research

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Authors: Wang L, Lakin J, Riley C, Korach Z, Frain LN, Zhou L Abstract Despite the increasing prevalence, growing costs, and high mortality of dementia in older adults in the U.S., little is known about the course of these diseases and what care dementia patients receive in their final years of life. Using a large volume of clinical notes of dementia patients over the last two years of life, we conducted automatic topic modeling to capture the trends of various themes mentioned in care provider notes, including patients' physical function status, mental health, falls, nutrition and feeding, infections, hospital car...
Source: AMIA Annual Symposium Proceedings - Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research
CONCLUSIONS: Brexpiprazole 2 mg/day has the potential to be efficacious, safe, and well tolerated in the treatment of AAD. PMID: 31708380 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
This study examined in a large sample of dementia caregiving dyads the associations between both partners' reports of unmet needs in persons with dementia (PwDs) and both partners' health-related quality of life (HRQOL). METHODS: This was a cross-sectional self-report survey of 521 community-dwelling dyads in a pragmatic trial in the Netherlands. The Camberwell Needs Assessment was used to measure PwDs' unmet needs. Both partners' self-reported their HRQOL using the EuroQol-5. RESULTS: Controlling for covariates, PwDs' self-reported greater unmet needs were significantly associated with PwDs' and caregivers' lower ...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
DEMENTIA is a progressive neurological condition that can be highly distressing for the person affected and loved ones. Fortunately, making positive changes to one ’s lifestyle can reduce the risk of developing the brain condition and slow down the onset of symptoms, and evidence points to a particular activity.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
(Alzheimer's Association) 5-year grant aimed at identifying evidence-based strategies to enhance care and support for individuals with dementia and their care partners.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Alzheimer’s disease (AD) is a neurodegenerative disease and the main cause of dementia. Its major symptom is memory loss, which is a result of neuronal cell death, which is accompanied by neuroinflammation. Some studies indicate the overactivation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway in this disease, being, thus, a potential target for pharmacological treatment. Here, we used a transgenic mouse model of AD that expresses a mutant amyloid-β precursor protein (T41 mice) to investigate the effects of dactolisib (alternative name: NVP-BEZ23...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Photo credit Wenni Zhou Dear Carol: When my husband started having some rather bizarre behavioral episodes, he made an appointment for a checkup. After an exam didn’t show problems, the doctor referred him to a neurologist who conducted some tests and diagnosed him with Alzheimer’s. Because my husband didn’t have memory problems that are unusual for his age, I wasn’t satisfied, so we saw another neurologist. She diagnosed my husband with mixed dementia with signs of Alzheimer’s, but also vascular dementia. This diagnosis seems odd to me, too. Aren’t memory problems the hallmark of A...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
AbstractCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic disease leading to stroke and vascular dementia. CADASIL is an inherited small blood vessel disease caused by mutations in the gene encoding the neurogenic locus notch homolog protein 3 (NOTCH3). NOTCH3 is large type I membrane receptor mainly expressed in vascular smooth muscle cells and pericytes. Most identified mutations result in insert or deletion of a cysteine residue within the EGF-like repeats. To date, some cases with a cysteine-sparing mutant have been described. Genetic analy...
Source: Neurogenetics - Category: Genetics & Stem Cells Source Type: research
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