Role of the Department of Defense Hearing Center of Excellence in Studying the Treatment of Tinnitus
Against poor odds, Formby and colleagues managed to receive federal grant funding for a multisite clinical trial, to access and convince military investigators to join in this trial, to select rigorous measures and methods when no objective tinnitus measurement exists, and to gain approvals from all levels of regulatory and local command authority oversight bodies across 6 military treatment facilities before they could start their effort to complete the Tinnitus Retraining Therapy Trial (TRTT), described by Scherer and Formby in this issue ofJAMA Otolaryngology –Head&Neck Surgery. In just shy of 20 years from the time planning and organization for the study began, they completed data collection from 130 individuals. With a paucity of trials to evaluate this tinnitus management strategy, the contribution of Scherer and Formby to the literature is a success story in perseverance. The logistics, study inclusion criteria, and training of the clinical staff in TRTT were tasks that appeared at first to be insurmountable, but ultimately were successful.
Publication date: July–August 2019Source: Brain Stimulation, Volume 12, Issue 4Author(s): William F. Stubbeman, Monica Nable, Annah Ramones, Melodi Gencosmanoglu, Raya Khairkhah
Objective: To present the case reports of two patients with chronic broadband tinnitus who showed improvement following sound paired 20 Hz theta burst (TBS-20Hz) transcranial magnetic stimulation (TMS) and to analyze one patient ’s structural brain changes following treatment.
ConclusionsIt was possible to prove the effectiveness of the hearing aids and/or G. biloba extract EGb 761 treatment, which shows success in the control of tinnitus contributing to the improvement of this symptom.ResumoIntroduçãoO zumbido é definido como a percepção de um som sem a sua presença real no ambiente e tem sido objeto de um grande número de estudos, especialmente devido às suas consequências na qualidade de vida do paciente.ObjetivoEste estudo objetivou investigar o efeito de próteses auditivas e / ou extrato de Ginkgo biloba EGb 761 sobre o zu...
PURPOSE The aim of this study was to explore the relationship between parental mental illness in childhood with suicidal and self-harm ideations in adults seeking help for their tinnitus and/or hyperacusis. METHOD This was a retrospective, cross-se...
CONCLUSION: Our study supports the concept of NVCC in VP and additionally suggests that nerve angulation may be a specific feature. Neurovascular contact remains a common phenomenon in asymptomatic patients and therefore correlation with neuro-otology assessment remains essential. PMID: 31205008 [PubMed - as supplied by publisher]
The condition was stopped in mice by blocking a protein that fuels brain inflammation. The Arizona team are hopeful it will lead to a gene therapy to combat tinnitus and other hearing loss disorders.
(PLOS) Inflammation in a sound-processing region of the brain mediates ringing in the ears in mice that have noise-induced hearing loss, according to a study publishing June 18, 2019, in the open-access journal PLOS Biology by Shaowen Bao of the University of Arizona, and colleagues.
We examined neuroinflammation in the auditory cortex following noise-induced hearing loss (NIHL) and its role in tinnitus in rodent models. Our results indicate that NIHL is associated with elevated expression of proinflammatory cytokines and microglial activation—two defining features of neuroinfla mmatory responses—in the primary auditory cortex (AI). Genetic knockout of tumor necrosis factor alpha (TNF-α) or pharmacologically blocking TNF-α expression prevented neuroinflammation and ameliorated the behavioral phenotype associated with tinnitus in mice with NIHL. Conversely, infusion of T NF-&alph...
Will.i.am has certainly made a name for himself in the music world storming the charts with his band, Black Eyed Peas. The music legend discusses his scary discovery when a constant ring in his head turned out to be tinnitus.