ΜicroRNA‑889 plays a suppressive role in cell proliferation and invasion by directly targeting TAB1 in non‑small cell lung cancer.

ΜicroRNA‑889 plays a suppressive role in cell proliferation and invasion by directly targeting TAB1 in non‑small cell lung cancer. Mol Med Rep. 2019 May 15;: Authors: Dong Z, Li B, Wang X Abstract MicroRNAs (miRNAs) are frequently reported to be aberrantly expressed in non‑small cell lung cancer (NSCLC) and are closely associated with aggressive tumor phenotypes. Hence, identification of cancer‑related miRNAs in NSCLC may be helpful for improving the cure rate of NSCLC treatments. miR‑889 has been demonstrated to be a novel cancer‑associated miRNA that is aberrantly expressed and plays an important role in esophageal squamous cell carcinoma and hepatocellular carcinoma. However, the exact functions and precise molecular mechanisms through which miR‑889 affects NSCLC progression are still unknown. In the present study, we report for the first time that miR‑889 expression is low in NSCLC tissues and cell lines. Clinically, low miR‑889 expression was found to be correlated with the TNM stage and distant metastasis in NSCLC patients. Functionally, miR‑889 overexpression suppressed the proliferation and invasiveness of NSCLC cells in vitro and decreased NSCLC xenograft tumor growth in mice. Furthermore, TGF‑β‑activated kinase 1‑binding protein 1 (TAB1) was confirmed as a direct target gene of miR‑889 in NSCLC cells. TAB1 was revealed to be overexpressed in NSCLC tissue samples and was inversely correlated wi...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research