Role of AHR in the control of GBM-associated myeloid cells

Publication date: Available online 23 May 2019Source: Seminars in Cancer BiologyAuthor(s): Galina Gabriely, Francisco J. QuintanaAbstractGlioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and modulate myeloid cells. The Aryl Hydrocarbon Receptor (AHR) is a ligand activated transcription factor implicated in the regulation of myeloid cells. In this review, we will summarize current knowledge on the AHR role in the control of myeloid cells and its impact on GBM pathogenesis.

Source: Seminars in Cancer Biology - May 23, 2019 Category: Cancer & Oncology Source Type: research