Early interventions to prevent psychosis: systematic review and meta-analysis

Source: BMJ Area: News According to the results of a systematic review and meta-analysis, psychological interventions such as cognitive behavioural therapy (CBT) may help to delay or prevent psychosis in high-risk individuals.   The authors note that the incidence of probable psychosis is around 5 per 1000 adults in the UK. Schizophrenia, the most common form of psychosis and one of the leading causes of long-term disability, is usually preceded by a prodromal period.  Interventions that delay or prevent transition to psychosis from this prodromal syndrome could be clinically and economically important.   The purpose of their systematic review and meta-analysis was to determine whether any psychological, pharmacological, or nutritional interventions can prevent or delay transition to psychotic disorders for people at high risk. Although a previous review of such early interventions found only limited evidence, the searches were completed in 2009 and several studies have been ...
Source: NeLM - Mental Health - Category: Psychiatry Source Type: news

Related Links:

In this study, we employed a gene-set analysis approach to address this issue. Four neuropsychiatric disorders were studied, including schizophrenia (SCZ), autistic spectrum disorders (ASD), intellectual disability (ID) and epilepsy. We first identified gene-sets associated with different drugs, and analyzed whether the gene-set pertaining to each drug overlaps with DNMs more than expected by chance. We also assessed which medication classes are enriched among the prioritized drugs. We discovered that neuropsychiatric drug classes were indeed significantly enriched for DNMs of all four disorders; in particular, antipsychot...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
 Those of us with mental illness are asked many questions about our feelings. For a lot of us, the most difficult one to answer is, “Are you happy?” It’s a difficult question to answer because happiness isn’t an easily defined concept. Most people assume that in order to be in recovery from mental illness a person must be happy. But is that really the case? Listen in to this episode to hear our thoughts on happiness, regret, and even a side story about Gabe’s first marriage.   SUBSCRIBE &REVIEW “People just want to be happy and normal, but there is no actual defi...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Depression Happiness Schizophrenia Source Type: blogs
Authors: Silberstein J, Harvey PD Abstract INTRODUCTION: Individuals with schizophrenia present across a spectrum of symptomatology. Disability remains a debilitating reality across varying disease presentations and remains pervasive despite psychiatric medications. Cognition (neuro/social cognition) and negative symptoms have emerged as the strongest predictors of real-world disability, but account for
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
A new self-rating functional scale (SRFS) was developed to assess the functionality of patients with schizophrenia, referred to the structure of Personal and Social Performance Scale (PSP). The main aim of this study was to evaluate the reliability and validity of the SRFS. A total of 210 patients with schizophrenia were recruited from outpatient clinics in six sites in China. Demographic information, SRFS, PSP, World Health Organization Disability Assessment Schedule II, and Positive and Negative Syndrome Scale were assessed. Spearman’s correlation coefficient and path analysis were used to assess the reliability an...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: ORIGINAL ARTICLES Source Type: research
CONCLUSIONS: The level of evidence for the use of medical MJ among people with disabilities varies greatly, and has a clear lack of methodologically sound studies. Overall, medical MJ does not improve the level of functioning, but it may improve the overall quality of life for people with disabilities. Implications for Rehabilitation Epilepsy can be a disabling chronic disorder which not only impacts physically but can restricts quality of life. Quality of life is diminished even more with treatment resistant epilepsy. Chronic pain is the leading cause of disability and is the most common cause of long-term disability. The...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Abstract VGF nerve growth factor inducible (VGF) is a neuropeptide precursor induced by brain-derived neurotrophic factor and nerve growth factor. VGF is increased in the prefrontal cortex and cerebrospinal fluid in schizophrenia patients. In our previous study, VGF-overexpressing mice exhibited schizophrenia-like behaviors and smaller brain weights. Brain developmental abnormality is one cause of mental illness. Research on brain development is important for discovery of pathogenesis of mental disorders. In the present study, we investigated the role of VGF on cerebellar development. We performed a histological a...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research
CONCLUSION: The survey revealed high mental morbidity and alarming treatment gap. FGDs and KIIs also highlight the burden of morbidity that probably goes un-noticed, due to socio-cultural systems and stigma. Findings from this survey are intended to be the groundwork for the (re)planning of mental healthcare infrastructure in the state. PMID: 30412821 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
One of the most important advances in treating serious mental illness in recent years is improving care for people experiencing a first onset of serious mental illness such as psychosis, schizophrenia, bi-polar disorder and other conditions. It is known that early phases of mental illness can be identified, and then team-based coordinated specialty care treatment reduces the likelihood of long term disability. SAMHSA’s (Substance Abuse and Mental Health Services Administration) new Early Serious Mental Illness Treatment Locator will help connect people experiencing a first onset of serious mental illness to effective...
Source: BHIC - Category: Databases & Libraries Authors: Tags: Mental Health Source Type: blogs
Authors: Díaz-Caneja CM, Cervilla JA, Haro JM, Arango C, de Portugal E Abstract BACKGROUND: Even if neurocognition is known to affect functional outcomes in schizophrenia, no previous study has explored the impact of cognition on functionality in delusional disorder (DD). We aimed to assess the effect of clinical characteristics, symptom dimensions and neuropsychological performance on psychosocial functioning and self-perceived functional impairment in DD. METHODS: Seventy-five patients with a SCID-I confirmed diagnosis of DD underwent neurocognitive testing using a neuropsychological battery examining ...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
CONCLUSION:: Childhood determinants were related to the risk of psychiatric disability pension before the age of 25. The risk factors varied by the diagnosis of the disability pension. Using knowledge of this study's risk factors should enable the identification of adolescents and young adults in general population and especially in the mental health care population who are at greatest risk of receipt of psychiatric disability pension. PMID: 30394811 [PubMed - as supplied by publisher]
Source: The International Journal of Social Psychiatry - Category: Psychiatry Authors: Tags: Int J Soc Psychiatry Source Type: research
More News: Behavioural Therapy | Cognitive Behavior Therapy | Disability | Health | Men | Nutrition | Psychiatry | Psychology | Schizophrenia | Study