Early interventions to prevent psychosis: systematic review and meta-analysis

Source: BMJ Area: News According to the results of a systematic review and meta-analysis, psychological interventions such as cognitive behavioural therapy (CBT) may help to delay or prevent psychosis in high-risk individuals.   The authors note that the incidence of probable psychosis is around 5 per 1000 adults in the UK. Schizophrenia, the most common form of psychosis and one of the leading causes of long-term disability, is usually preceded by a prodromal period.  Interventions that delay or prevent transition to psychosis from this prodromal syndrome could be clinically and economically important.   The purpose of their systematic review and meta-analysis was to determine whether any psychological, pharmacological, or nutritional interventions can prevent or delay transition to psychotic disorders for people at high risk. Although a previous review of such early interventions found only limited evidence, the searches were completed in 2009 and several studies have been ...
Source: NeLM - Mental Health - Category: Psychiatry Source Type: news

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ConclusionsThe addition of texting to patients and their lay health supporters in a resource-poor community setting was more effective than a free-medicine program alone in improving medication adherence and reducing relapses and re-hospitalizations. Future studies may test the effectiveness of customization of the texting to individual patients. Trial registrationChinese Clinical Trial Registry ChiCTR-ICR-15006053.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
This study presents findings from a large sample with extensive clinical phenotyping—allowing us to examine the relationships of insulin resistance with a number of key psychopathological, cognitive, and functioning measures, using multivariate methods to assess the relative contributions of different factors to metabolic abnormalities. PwS often have many risk factors for metabolic abnormalities: lifestyle habits, medications, and underlying biological mechanisms including inflammation and oxidative stress. Treatment and prevention of metabolic abnormalities in PwS can be particularly challenging due to these multip...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Vincent Negatsch1*, Alexander Voulgaris2, Peter Seidel3, Robert Roehle4,5,6 and Annette Opitz-Welke11Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Forensic Psychiatry, Berlin, Germany2Universitätsklinikum Hamburg-Eppendorf, Institute of Sexual Medicine and Forensic Psychiatry, Hamburg, Germany3Department of Psychiatry and Psychotherapy, Prison Hospital Berlin, Berlin, Germany4Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractLittle is known about the changes of people with schizophrenia disability in Taiwan who receive routine treatments under the current mental healthcare system. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to assess and track changes in the degree of disability in people with schizophrenia before and after 4 years of follow-up. Data on 4497 people with schizophrenia were acquired from the Taiwan Data Bank of Persons with Disability. The WHODAS 2.0 was used for disability assessment, and the chi-square test, logistic regression and generalised estimating equations were adopted...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Magnetic Resonance Imaging (MRI) can now be used in conjunction with machine learning to predict cognitive development in infants,  according to a  studyrecently published inNeuroImage.White matter is intrinsic to developing brain activity, and the white matter connectome at birth can be used as a neuroimaging biomarker to calculate cognitive development. The group of researchers led by Jessica B. Girault, PhD, from the Carolina Institute for Developmental Disabilities at the University of North Carolina Chapel Hill are searching for imaging biomarkers like white matter to determine risks for neuropsychiatric con...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Tatsuya Daikoku1,2* and Masato Yumoto1 1Department of Clinical Laboratory, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan 2Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany In an auditory environment, humans are frequently exposed to overlapping sound sequences such as those made by human voices and musical instruments, and we can acquire information embedded in these sequences via attentional and nonattentional accesses. Whether the knowledge acquired by attentional accesses interacts with that acquired by nonattentional accesses is...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Dominic Oliver1,2, Joaquim Radua1,3,4, Abraham Reichenberg5,6,7,8, Rudolf Uher9 and Paolo Fusar-Poli1,2,10,11* 1Early Psychosis: Interventions and Clinical Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom 2OASIS Service, South London and the Maudsley NHS Foundation Trust, London, United Kingdom 3Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain 4Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockh...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionThe research project aims to directly improve identification and support of vulnerable children across selected regions in Austria, and by doing so, improve the health and well-being of future Austrian generations while breaking the cycle of intergenerational transfer of adverse childhood experiences. The described project underwent a rigorous public review process (https://ois.lbg.ac.at/en/methods-projects/crowdsourcing-research-questions-in-science) with different stakeholders as well as people with lived experience and scientific experts of the field having reviewed our proposal (https://ois.lbg.ac.at/en/metho...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions: CBT, psychosocial intervention, supportive counseling, psychodynamic psychotherapy, and other psychological interventions can be recommended for clinical practice. More studies are needed, especially for non-CBT interventions and for all psychotherapies on negative symptoms.IntroductionSchizophrenia affects approximately 1% of the population, usually starting in adolescence or young adulthood, frequently leading to persistent disability, with a high risk of suicide (8%). Despite the advance in antipsychotics treatment, approximately 30% of patients with schizophrenia show a poor response or no response to anti...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions: Our results do not support investment in a large-scale trial in England at this time.Trial registration: UK CRN Portfolio database, Trial ID: ISRCTN19689576.Trial funding: National Institute of Health Research (RP-PG-0707-10093).IntroductionIn England, one third of working-age adults with severe mental health problems (around 60,000 people) reside in supported accommodation provided by health and social services and housing associations (1, 2). These services have been categorised into three main types (3): residential care homes (offering high levels of longer-term support, 24 h a day to individuals with high...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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