Reduced endothelial nitric oxide synthase activation contributes to cardiovascular injury during chronic kidney disease progression.
Reduced endothelial nitric oxide synthase activation contributes to cardiovascular injury during chronic kidney disease progression.
Am J Physiol Renal Physiol. 2019 May 22;:
Authors: Amador-Martínez I, Pérez-Villalva R, Uribe N, Cortés-González C, Bobadilla NA, Barrera-Chimal J
Abstract
Major cardiovascular events are a common complication in chronic kidney disease (CKD) patients. Endothelial dysfunction can contribute to the cardiovascular injury observed in CKD. Here, we used a rat model of acute kidney injury to CKD transition to investigate heart alterations in the pathway activating endothelial nitric oxide synthase (eNOS) and its impact on the cardiac injury observed during CKD progression. Fifty male Wistar rats were divided into sham surgery (n=25) or rats subjected to bilateral renal ischemia-reperfusion (IR-CKD) for 45 min (n=25). The rats were studied on a monthly basis up to five months (n=5). In another set of sham and IR-CKD rats, L-arginine was administered starting on the third month after the renal ischemia. CKD development and cardiac alterations were monitored in all groups. CKD was characterized by a progressive increase in proteinuria and renal dysfunction that was evident after the fifth month of follow-up. Heart hypertrophy was observed starting on the fourth month after IR. There was a significant increase in brain natriuretic peptide levels. In the heart, IR-CKD rats had increased eNOS phosphorylation at...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Amador-Martínez I, Pérez-Villalva R, Uribe N, Cortés-González C, Bobadilla NA, Barrera-Chimal J Tags: Am J Physiol Renal Physiol Source Type: research
More News: Brain | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chronic Kidney Disease | Heart | Neurology | Physiology | Proteinuria | Urology & Nephrology