Matrix metalloproteinases (MMPs) and inhibitor of metalloproteinases (TIMP) mRNA and protein expression in laryngeal squamous cell carcinoma.

Matrix metalloproteinases (MMPs) and inhibitor of metalloproteinases (TIMP) mRNA and protein expression in laryngeal squamous cell carcinoma. Arch Med Sci. 2019 May;15(3):784-791 Authors: Grzelczyk WL, Wróbel-Roztropiński A, Szemraj J, Cybula M, Pietruszewska W, Zielińska-Kaźmierska B, Jozefowicz-Korczynska M Abstract Introduction: The aim of the study was to investigate the mRNA expression and protein levels of matrix metalloproteinases (MMP) 2 (MMP-2), 9 (MMP-9), 7 (MMP-7) and their tissue inhibitor TIMP-2 in patients with laryngeal squamous cell carcinoma and control subjects and additionally to evaluate a possible correlation with clinicopathological features. Material and methods: The expression levels of MMP-2, MMP-9, MMP-7, and TIMP-2 mRNA were detected by the real-time quantitative real time polymerase chain reaction method in 96 cases of laryngeal carcinoma vs. non-tumor tissue. The blood serum levels of MMP-2, MMP-9, MMP-7, and TIMP-2 in patients with laryngeal cancer and 100 healthy subjects were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: The present study demonstrated that MMP-2, MMP-7, MMP-9 and TIMP-2 mRNA expression levels in carcinoma tissue vs. non-tumor tissue and protein levels in the preoperative serum vs. those obtained in healthy controls were statistically significantly higher than in the healthy controls (p = 0.001). The only significant correlation between mRNA or concentration ...
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research

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ABSTRACT Purpose To evaluate the expression levels of Matrix metalloproteinases-1 (MMP-1) on Laryngeal Squamous Cell Carcinoma (LSCC) and improve the early diagnosis rate via ultrasound molecular imaging (USMI). Methods The microsized MMP-1-targeted microbubbles (MBMMP-1) and the control MBs (MBIgG) based on perfluorocarbon-filled lipid-shelled were constructed and characterized. The in vitro, binding experiment was performed with human epidermoid laryngeal cancer cells (HEp-2) and tested the binding efficiency of MBMMP-1 and MBIgG was tested. In the in vivo study, the LSCC model was established in 10 mice. The MBMMP-1...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
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