NIAID announces two awards for multi-year studies of influenza immunity in children
(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has announced two awards for the study of influenza immunity in children. The awards, which may total more than $64 million over seven years, will support studies led by Cincinnati Children's Hospital Medical Center and St. Jude Children's Research Hospital, examining how young children's immune systems respond over multiple years to their initial influenza infection and their first vaccination.
Abstract Acute otitis media (AOM) is the most common diagnosis in childhood acute sick visits. By three years of age, 50% to 85% of children will have at least one episode of AOM. Symptoms may include ear pain (rubbing, tugging, or holding the ear may be a sign of pain), fever, irritability, otorrhea, anorexia, and sometimes vomiting or lethargy. AOM is diagnosed in symptomatic children with moderate to severe bulging of the tympanic membrane or new-onset otorrhea not caused by acute otitis externa, and in children with mild bulging and either recent-onset ear pain (less than 48 hours) or intense erythema of the t...
Condition: Healthy Volunteer Interventions: Biological: Flucelvax; Biological: Fluvirin; Biological: Fluzone High Dose Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting
AbstractPurpose of ReviewAnaphylaxis is a rare, serious hypersensitivity reaction following vaccination, which is rapid in onset and characterized by multisystem involvement. Although anaphylaxis may occur after any vaccine, understanding the risk for this outcome, particularly following influenza vaccines, is important because of the large number of persons vaccinated annually.Recent FindingsTwo recent CDC safety studies confirmed the rarity of post-vaccination anaphylaxis. In a 25-year review of data from the Vaccine Adverse Event Reporting System (VAERS), reports in children were most common following childhood vaccinat...
(NIH/National Institute of Allergy and Infectious Diseases) A study of influenza virus transmission in Nicaraguan households reveals new insights into the type of immune responses that may be protective against influenza virus infection, report investigators. The findings could help scientists design more effective influenza vaccines and lead to the development of novel universal influenza vaccines. The research was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Conditions: Influenza; Influenza Immunisation Interventions: Biological: Advax-CpG55.2; Drug: AF03; Biological: Influenza Virus Quadrivalent Inactivated Vaccine; Biological: Quadrivalent Recombinant Seasonal Influenza Vaccine Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting