Chapter 10 - Functionalized magnetic nanoparticles/biopolymer hybrids: Synthesis methods, properties and biomedical applications

Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Kakarla Raghava Reddy, Pattubala Adinaraya Reddy, Chandragiri Venkata Reddy, Nagaraj P. Shetti, Bhatula Babu, Koutavarapu Ravindranadh, Muthukonda Venkatakrishnan Shankar, Madhava C. Reddy, Sarvesh Soni, Shivalingegowda NaveenAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most extensively used functional nanomaterials as antibacterial agents, and for other biomedical applications due to their unique physical, chemical, magnetic and biocompatibility properties. However, due to their small size, particles tend to aggregate by dipole-dipole interactions between magnetic particles, restricting the type of application they can be used for in precision medicine. Therefore, surface modification on SPIONs is required to enhance their properties and biomedical applications. This review summarizes the different synthesis methodologies for preparing magnetic ferrite nanoparticles, and their functionalization with various biopolymers, physico-chemical, magnetic and biological properties of magnetic ferrite particles-functionalized biopolymers, their applications as antibacterial agents, and as magnetic resonance imaging (MRI) contrast agents uses in clinical diagnostic medicine. Various types of substituted ferrite-based nanoparticles were also showed excellent antibacterial properties against different bacteria such as S. aureus, B. subtilis, E. coli, P. aeruginosa, S. marcescens, M. varians,...
Source: Methods in Microbiology - Category: Microbiology Source Type: research

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Publication date: Available online 10 May 2019Source: Methods in MicrobiologyAuthor(s): Kakarla Raghava Reddy, P. Adinaraya Reddy, Ch. Venkata Reddy, Nagaraj P. Shetti, B. Babu, K. Ravindranadh, M.V. Shankar, Madhava C. Reddy, Sarvesh K. Soni, S. NaveenAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most extensively used functional nanomaterials as antibacterial agents, and for other biomedical applications due to their unique physical, chemical, magnetic and biocompatibility properties. However, due to their small size, particles tend to aggregate by dipole-dipole interactions between magnetic particle...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
To investigate clinical risk factors for acute magnetic resonance imaging (MRI) abnormalities in patients with benign convulsions with mild gastroenteritis (CwG) or benign infantile epilepsy (BIE).
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Research Paper Source Type: research
Publication date: Available online 3 May 2019Source: IDCasesAuthor(s): Ana Rita Nogueira, Sofia Brazão, Diana Ferreira, António Aragão, Manuel Teixeira Veríssimo, Armando CarvalhoAbstractEscherichia coli (E.coli) is a rare cause of endocarditis, although is a common causative agent of bacteremia. An 89-year-old woman presented with recurrent episodes of fever and persistent E. coli bacteremia with 3-month duration, despite antimicrobial therapy. At first, a urinary tract infection was diagnosed and later a mycotic aneurysm of the abdominal aorta was found and required an endovascular repair. The...
Source: IDCases - Category: Infectious Diseases Source Type: research
Authors: Ujihara T, Yamamoto K, Kitaura T, Katanami Y, Kutsuna S, Takeshita N, Hayakawa K, Ohmagari N Abstract A 75-year-old woman was admitted with urosepsis due to Escherichia coli infection. After improvement with a ureteral stent and antimicrobial agent, she complained of back pain and showed elevated inflammation marker levels. Arthralgia and arthritis of multiple peripheral joints were noted, and radiography indicated cartilage calcification. Magnetic resonance imaging revealed lumbar facet joint effusion. Her symptoms improved with nonsteroidal anti-inflammatory drug administration. Thus, she was diagnosed w...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionsA “neurological score” may be a useful tool to drive the early treatment of CNS complications in STEC-HUS with eculizumab, although future perspective controlled studies are urgently needed to validate this therapeutic approach.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Although acute osteomyelitis is rare in neonates, it might result in severe sequelae such as joint destruction and growth failure if it is not diagnosed and treated early. However, few studies have focused on the clinical features and treatment of this disease. A retrospective review of 17 cases of neonatal osteomyelitis, for which the patients underwent medical treatment alone or combined with surgery at the Children's Hospital of Zhejiang University School of Medicine between January 2009 and September 2016, was conducted. Medical treatment included the use of antibiotics and supportive care. Surgery was performed in ca...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Rationale: Myasthenia gravis (MG) is an uncommon autoimmune disease mediated by antibodies that attack the postsynaptic acetylcholine receptors (AchRs) at the neuromuscular junction, causing fluctuating muscle weakness, aggravated with use, and relieved with rest. Patient concerns: A 32-year-old woman with a diagnosis of MG based on clinical findings, eletroneuromyography, and brain magnetic resonance imaging (MRI) was admitted to our hospital with dysphagia, dysphonia, diplopia, and intense weakness, associated with a 2-day viral gastroenteritis. Diagnoses: Physical examination revealed globally reduced deep tendo...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusions Many ED referrals directed from urgent care centers in our sample were considered essential, and few were considered serious. Urgent care centers should develop educational and preparedness strategies based on the epidemiology of emergencies that may occur.
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Original Articles Source Type: research
CONCLUSION: Despite a significant reduction in paediatric inpatient mortality in Malawi, infectious diseases remain the predominant cause. ABBREVIATIONS: ART: anti-retroviral therapy; Child PIP: Child Healthcare Problem Identification Programme; CCF: congestive cardiac failure; CNS: central nervous system; CoNS: coagulase-negative staphylococci; CSF: cerebrospinal fluid; DNA pcr: deoxyribonucleic acid polymerase chain reaction; ETAT: emergency triage assessment and treatment; LMIC: low- and middle-income countries; MDG: Millennium Development Goals; MRI: magnetic resonance imaging; MRSA: methicillin-resistant Staphyloc...
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
ConclusionSpondylodiscitis should be considered for all patients presenting with chronic LBP with systemic symptoms and evidence inflammation. MRI is required to establish a diagnosis and evaluate the spread of infection. CT-PDB is useful to identify the causative micro-organism before antibiotic administration. These findings could to pave the way for constructing national guidelines.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
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