Repair of Adult Mammalian Heart After Damages by Oral Intake of Gu Ben Pei Yuan San

ABSTRACT Adult mammalian heart repair after myocardial damage is highly inefficient due to the post-mitotic nature of cardiomyocytes. Interestingly, in Traditional Chinese Medicine (TCM), there are reported effective treatments of myocardial infarction and heart failure in adult humans by oral intake of a TCM concoction named Gu Ben Pei Yuan San (GBPYS) which is composed of Panax ginseng, Velvet antler, Gekko gecko linnaeus tail, Human placenta, Trogopterus dung, Panax notoginseng, and Amber. We fed the mice with GBPYS after myocardial damages through everyday self-feeding. We then examined the effect of everyday oral intake of GBPYS on improving cardiac function and myocardial repair in adult mice after apical resection or myocardial infarction. We found that long-term oral intake of GBPYS significantly improved cardiac function after myocardial damages in adult mice. Brdu, Phospho-histone 3, and AuroraB staining indicated increased cell proliferation at the border zone of MI after TCM feeding. GBPYS feeding reduced organ inflammation and is nontoxic to mice after long-term oral intake. Further, serum derived from TCM fed MI rats promoted division of both neonatal rat cardiomyocytes and human iPSC-derived cardiomyocytes In vitro. Oral intake of GBPYS improved heart repair after myocardial damages in adult mice. Our results suggest that there are substances present in GBPYS that help improve adult mammalian heart repair after MI. Also, it could be a good choice of non-invasi...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Conclusions: The mFI-5 is an independent predictor of postoperative morbidity and mortality in elderly patients undergoing surgery for hip fractures. This clinical tool can be used by hospitals and surgeons to identify high-risk patients, accurately council patients and families with transparency, and guide perioperative care to optimize patient outcomes. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
CHELMSFORD, Mass.--(BUSINESS WIRE)--Jun 18, 2019--ZOLL ®  Medical Corporation, an Asahi Kasei Group Company that manufactures medical devices and related software solutions, today announced it has acquired TherOx, Inc., of Irvine, Calif., a privately held company. TherOx is focused on improving treatment of acute myocardial infarction (AMI) and markets systems to deliver SuperSaturated Oxygen (SSO 2 ) Therapy. SSO 2 Therapy, which was recently approved by the Federal Drug Administration (FDA), has been demonstrated to reduce infarct size after primary coronary intervention (PCI) with stenting in patients wi...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Tags: News Industry News Source Type: news
Myocardial infarction (MI), via change of either the structure and/or the functioning, is a common cause of the heart failure [1]. The main characteristic of MI-induced heart failure is reduced ejection fraction (HFrEF). The current first line treatment strategy (long-duration pharmacologic therapy) carries adverse remodeling risks [2,3]. Newer strategies reducing recurrent adverse remodeling as well as reinforce cardiac resynchronization are needed.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Fresh off receiving a PMA, TherOx is now in the process of being acquired by Zoll Medical, an Asahi Kasei Group Company.  Additional terms of the deal were not disclosed. Irvine, CA-based TherOX is focused on improving the treatment of acute myocardial infarction, and markets systems to deliver SuperSaturated Oxygen (SSO2) Therapy. The therapy has been demonstrated to reduce infarct size after primary coronary intervention (PCI) with stenting in patients with left anterior descending ST-elevation myocardial infarction. When a large ischemic area of muscle damage remains following AMI, the patient condition oft...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
Heart failure is a worldwide pandemic with an unacceptable high level of morbidity and mortality. Understanding the different pathophysiological mechanisms will contribute to prevention and individualized therapy of heart failure. We established mouse models for ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) by inducing myocardial infarction and Coxsackievirus B3 infection respectively. Isobaric tags for relative and absolute quantitation and liquid chromatography coupled with tandem mass spectrometry technology was used to identify the protein expression profiles in control and failing hearts. A total of 1...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 16 June 2019Source: Pharmacological ResearchAuthor(s): Vasundhara Kain, Jeevan Kumar Jadapalli, Bochra Tourki, Ganesh V. HaladeAbstractLifestyle or age-related risk factors over-activate the inflammation that triggers acute heart failure (HF)-related mortality following myocardial infarction (MI). Post-MI activated leukocytes express formyl peptide receptor 2 (FPR2) that is essential for inflammation-resolution and in cardiac healing. However, the role of FPR2 in acute HF is incomplete and remain of interest. Here, we aimed to determine whether pharmacological inhibition of FPR2 perturb l...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
The innate immune cells known as macrophages play an important role in the coordination of regeneration, in addition to their tasks related to defense against pathogens and clearance of debris and molecular waste. Macrophages adopt different polarizations, or collections of behaviors, under different circumstances. Researchers are very interested in finding ways to force macrophages to adopt a desired polarization, such as to switch inflammatory, aggressive macrophages into a kinder, gentler pro-regeneration state. The research noted here is an example of those efforts, in that the scientists involved are attempting to mak...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
CONCLUSION: Typhaneoside regulates IL-6 and TNF-α as well as MMP-2 and MMP-9 in rats with heart failure after myocardial infarction. Typhaneoside can improve cardiac morphological structure and myocardial remodeling and enhance heart function. It may mediate autophagy inhibition in the cardiomyocyte anoxia/reoxygenation (A/R) pathway through the PI3K/Akt/mTOR autophagy transduction pathway. PMID: 31201434 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
ConclusionsAmong patients with type  2 diabetes mellitus after a recent acute coronary syndrome or acute ischemic stroke, treatment with vildagliptin was not associated with increased risks of CV death, non‐fatal myocardial infarction, non‐fatal stroke and hospitalization for HF.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
The objective of this study was to investigate the vulnerability of hearts with aging, LVH, diabetes, and pregnancy to ischemic insult and their response to pacing postconditioning- (PPC-) induced heart protection. Methods: Hearts isolated from aged, spontaneously hypertensive and diabetic male and female rats and hearts from pregnant female rats (n=8 per group) were subjected to coronary occlusion followed by reperfusion using a modified Langendorff system. Hemodynamics data were computed digitally, and cardiac damage was accessed by measurements of infarct size and cardiac enzyme release. Results: There were no...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
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