State of the art – sirtuin 1 in kidney pathology – clinical relevance

Publication date: September 2019Source: Advances in Medical Sciences, Volume 64, Issue 2Author(s): Angelika Bazyluk, Jolanta Malyszko, Tomasz Hryszko, Edyta ZbrochAbstractSirtuins represent a group of nicotinamide adenine dinucleotide dependent histone deacetylases, which regulates various biological pathways by promoting chromatin silencing and transcriptional repression. Therefore, they are linked to cellular energy metabolism, mitochondrial biogenesis, stress response, apoptosis, inflammation and fibrosis. Since sirtuin 1 became a promising candidate for targeted therapies of numerous conditions, researchers have been investigating its activator. As for now, natural agents and antidiabetic drug – metformin, have been found to activate sirtuin 1. Sirtuin 1 is able to improve kidney outcomes by direct impact on kidney cells, regulation of non-specific processes generally involved in pathogenesis of age–dependent and metabolic disorders and improvement of the comorbid diseases. This review discusses the state of the art knowledge on the role of sirtuin 1 on kidney pathology.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research