Molecules, Vol. 24, Pages 1970: Antimicrobial, Antioxidant Activities, and HPLC Determination of the Major Components of Verbena carolina (Verbenaceae)

Molecules, Vol. 24, Pages 1970: Antimicrobial, Antioxidant Activities, and HPLC Determination of the Major Components of Verbena carolina (Verbenaceae) Molecules doi: 10.3390/molecules24101970 Authors: Gonzalo Lara-Issasi Cecilia Salgado José Pedraza-Chaverri Omar N. Medina-Campos Agustín Morales Marco A. Águila Margarita Avilés Blanca E. Rivero-Cruz Víctor Navarro Ramiro Ríos-Gómez María Isabel Aguilar Verbena carolina L. (Verbenaceae) is used as a decoction in Mexican folk medicine with applications against digestive problems and for dermatological infections. The present work firstly reported HPLC analysis, as well as the free radical scavenging capacity of the extracts and isolated compounds. Antimicrobial analyses of these substances against the bacteria Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Salmonella typhi and the fungi Candida albicans, Trichophyton mentagrophytes and T. rubrum were also tested, as well as the acute oral toxicity in mice of aqueous extracts. Major secondary metabolites in V. carolina extracts were isolated by conventional phytochemical methods which consisted of three terpenoids ((1), (3) and (4)) and four phenolic compounds ((2), (4)–(6)). Their contents were determined by HPLC in six different samples from different locations. The results indicated that ursolic acid (1), hispidulin (2), verbenaline (3), hastatoside (4), verbascoside (5), hispidulin 7-O-β-d-gl...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research