Three new ursane-type triterpenoids from the roots of Sanguisorba officinalis L. and their cytotoxic activity

Publication date: August 2019Source: Phytochemistry Letters, Volume 32Author(s): Rongshen Wang, Mei Jin, Chunshi Jin, Jinfeng Sun, Chao Ye, Tieqiang Zong, Guoqing Chen, Wei Zhou, Gao LiAbstractThree new ursane-type triterpenoids, 3-oxo-15α,19α-dihydroxyurs-12-en-28-oic acid (1), 3-oxo-7β,19α-dihydroxyurs-12-en-28-oic acid (2), and 18,19-seco,1β-hydroxyl-3,19-dioxo-urs-11,13(18)-dien-28-oic acid (3), together with eleven known triterpenoids (4 – 14) were isolated from the roots of Sanguisorba officinalis L. Their structures were characterized from spectroscopic data (1D, 2D NMR and HR-ESI-MS). All of the isolated compounds were evaluated for their cytotoxic activity against A549 cells. Compounds 1, 3, 5–8, 10, and 12 exhibited significant cytotoxic activity.Graphical abstract

Source: Phytochemistry Letters - May 22, 2019 Category: Chemistry Source Type: research