IJERPH, Vol. 16, Pages 1816: Brain Magnetic Resonance Imaging Findings in Children after Antenatal Maternal Depression Treatment, a Longitudinal Study Built on a Pilot Randomized Controlled Trial

IJERPH, Vol. 16, Pages 1816: Brain Magnetic Resonance Imaging Findings in Children after Antenatal Maternal Depression Treatment, a Longitudinal Study Built on a Pilot Randomized Controlled Trial International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16101816 Authors: Laura S. Bleker Jeannette Milgrom Donna Parker Alan W. Gemmill Christopher J. Holt Alan Connelly Huibert Burger Tessa J. Roseboom Susanne R. de Rooij Antenatal depression is associated with an increased risk of offspring neuro-developmental disorders, potentially as a consequence of an altered brain development in utero. We hypothesized that reducing maternal depression by Cognitive Behavioral Therapy (CBT) during pregnancy may ameliorate the offspring’s brain (micro)structural outcomes. 54 pregnant women with a diagnosed clinical depression were randomly allocated to CBT or Treatment as Usual (TAU), showing moderate to large depression symptom improvements after CBT. In 16 of their children (69% boys, N(TAU) = 8, N(CBT) = 8, mean age = 5.9 years, range = 3.9–7.1 years) brain Magnetic Resonance Imaging (MRI) scans were conducted. Children from the CBT group had a thicker right lateral occipital cortex (difference: 0.13 mm, 95% CI = 0.005–0.26) and lingual gyrus (difference: 0.18 mm, 95% CI = 0.01–0.34). In the CBT group, Voxel-Based Morphometry analysis identified one cluster showing increased gray matter concentration ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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Authors: Petralia MC, Mazzon E, Fagone P, Falzone L, Bramanti P, Nicoletti F, Basile MS Abstract Post-partum depression (PPD) occurs in approximately 20% of women usually early following child delivery. PPD represents an important unmet medical need as it is frequently underdiagnosed and, as the neurobiology of the disease is limitedly known, no pathogenic-tailored approach is available and only symptomatic medications are used. In the present study, we carried out a DNA microarray analysis to evaluate the fluctuation of cytokines, cytokine receptors and chemokines during the preconception period, the 1st and 3th t...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Abstract Prenatal alcohol exposure (PAE) is often associated with congenital heart defects, most commonly septal, valvular, and great vessel defects. However, there have been no known studies on whether PAE affects the resulting fibroblast population after development, and whether this has any consequences in the postnatal period. Our previous study focused on the effects of PAE on the postnatal fibroblast population, which translated into changes in cardiac extracellular matrix (ECM) composition and cardiac function in the neonatal heart. Moreover, our lab has previously demonstrated that alcohol-induced fibrosis...
Source: Toxicology Letters - Category: Toxicology Authors: Tags: Toxicol Lett Source Type: research
Conclusion: The results suggest early routine screening for anxiety and depressive symptoms amongst the Chinese pregnant women with a history of recurrent miscarriage. Health-care professionals should give more effort to enhance these women's social support to decrease their anxiety and depressive symptoms. PMID: 31411054 [PubMed - as supplied by publisher]
Source: Journal of Reproductive and Infant Psychology - Category: Psychiatry & Psychology Tags: J Reprod Infant Psychol Source Type: research
AbstractObjectivesFew studies have investigated the prophylactic efficacy of dexmedetomidine (DEX) in postpartum depressive symptoms (PDS). A randomized, double ‐blind, placebo‐controlled trial was conducted to investigate whether the administration of DEX, immediately after delivery and for patient controlled intravenous analgesia (PCIA), can attenuate PDS.MethodsSix hundred parturients scheduled for elective caesarean delivery under spinal anesthesia were randomly allocated into the Control group (infusion with 0.9%normal saline after delivery and PCIA with sufentanil) and the DEX group (DEX infusion 0.5ug.kg‐1 aft...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: Original Research Article Source Type: research
Publication date: November 2019Source: Infant Behavior and Development, Volume 57Author(s): Elisa Porter, Andrew J. Lewis, Stuart J. Watson, Megan GalballyAbstractPregnancy and the early post partum period are widely understood as a critical period for the infant’s emotional development and the earliest influence shaping social interaction. The present study aims to understand the potential influence of both antenatal and postnatal maternal anxiety and depressive symptoms on socio-emotional outcomes in offspring aged 12 months. The study used longitudinal data from a prospective cohort study on Australian pregnant wo...
Source: Infant Behavior and Development - Category: Child Development Source Type: research
This study fills that gap by including all mothers in specified areas. A cohort study examines MLH in Cape Town, South Africa recruited in pregnancy and followed repeatedly for 5  years, compared to MWOH. Almost all (98%) pregnant women in 12 neighborhoods (N = 594) were recruited in pregnancy. Mothers and children were reassessed five times over 5 years with high retention rates at each of the six assessments, from 98.7% at 2 weeks to 82.8% at 5 years post-birth. ML H’s uptake and adherence to HIV care was evaluated over time associated with maternal comorbidities of alcohol use, de...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
Conclusion: Depression symptoms early in pregnancy may represent a risk factor to increased paternal adjustment problems and negative paternal attitudes during the transition to parenthood. PMID: 31392897 [PubMed - as supplied by publisher]
Source: Journal of Reproductive and Infant Psychology - Category: Psychiatry & Psychology Tags: J Reprod Infant Psychol Source Type: research
Pregnancy and lactation are characterized by dramatic changes in the endocrine system and brain in mammalian females. These changes, with stress before pregnancy, are potential risk factors for the development...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Research Source Type: research
Conclusions: Women with increased antenatal levels of anxiety or depression symptoms are at increased risk of elevated levels of both postpartum depression and anxiety symptoms. Experiencing life events during pregnancy that were not related to the pregnancy was associated with higher levels of anxiety and depression in the postpartum period, as opposed to pregnancy-related events, delivery complications, or unfavorable obstetric outcomes. These results suggest that events during pregnancy but not related to the pregnancy and birth are a highly important predictor for postpartum mental health.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: Available online 10 July 2019Source: Current Medicine Research and PracticeAuthor(s): Roopa Satyanarayan Basutkar, Pooja Sudarsan, Chris Elizabeth Vinod, Resia Varghese, Divya Perumal, P. SivasankaranAbstractDepression is one of the most common turmoil encountered by pregnant women. Mothers’ suffering from antenatal depression holds a greater risk in developing postpartum depression. This increases the need for early detection of antenatal depression which could reduce further complications. Although there are several aetiologies for antenatal depression, iron deficiency anaemia (IDA) proves to be a...
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
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