Reduced Short-Latency Afferent Inhibition Indicates Impaired Sensorimotor Integrity During Migraine Attacks.

CONCLUSION: Pronounced decrease in SAI during preictal and ictal periods in migraine was shown for the first time. Instead of inhibition to a conditioned stimulus, facilitation in the sensorimotor cortex was detected both ictally and preictally. Preictal SAI results suggest the presence of increased excitability state several hours prior to the headache phase. This phenomenon could be related to the cortical hyperresponsivity to sensory stimuli and cognitive disturbances accompanying migraine attacks as SAI is modulated by cholinergic activity.
PMID: 31106418 [PubMed - as supplied by publisher]

Source: Headache - May 19, 2019 Category: Neurology Authors: Alaydin HC, Vuralli D, Keceli Y, Can E, Cengiz B, Bolay H Tags: Headache Source Type: research