Novel Smartphone Game Improves Physical Activity Behavior in Type 2 Diabetes
This study investigated whether a newly developed smartphone game delivering individualized exercise and physical activity promotion through an elaborate storyline can generate sustained improvements in daily physical activity (steps/day).Study designThirty-six participants were enrolled in this 24-week RCT between August 2016 and April 2018. After baseline assessment, participants were randomized in equal numbers to the intervention or control condition. Data analysis was performed in May–June 2018.Setting/participantsInactive, overweight type 2 diabetes patients, aged 45–70 years, were recruited through advertising and from hospitals and diabetes care centers in the Basel, Switzerland, metropolitan area.InterventionParticipants were instructed to play the innovative smartphone game (intervention group) or to implement the recommendations from the baseline lifestyle counseling (control group) autonomously during the 24-week intervention period.Main outcome measuresPrimary outcomes were changes in daily physical activity (steps/day); changes in aerobic capacity, measured as oxygen uptake at the first ventilatory threshold; and changes in glycemic control, measured as HbA1c.ResultsDaily physical activity increased by an average of 3,998 (SD=1,293) steps/day in the intervention group and by an average of 939 (SD=1,156) steps/day in the control group. The adjusted difference between the two groups was 3,128 steps/day (95% CI=2,313, 3,943, p
TYPE 2 diabetes is a common condition caused by the body ’s inability to produce enough insulin to regulate blood sugar levels. It is strongly linked to being overweight and poor dietary decisions. Sticking to a low-carb meal plan can help to mitigate the risks associated with the life-long condition.
ConclusionWe present a comprehensive mRNA expression profile of chromogranin A positive enteroendocrine cells following RYGB in rats. The data provides a region-specific characterization of all regulated preprohormone encoding genes in the rat GI tract including 16 not hitherto known. The comprehensive catalogue of preprohormone expression changes may support our understanding of hormone mediated effects of RYGB on diabetes remission and body weight reduction.Graphical abstract
In 2017 globally, 425 million adults were estimated to suffer from diabetes and it is estimated that 90% of all diabetic patients are diagnosed with type 2 diabetes mellitus (T2DM) . Type 2 diabetes mellitus is the most common type of diabetes among adults. The prevalence of T2DM is associated with obesity and unhealthy lifestyles .
ConclusionsSerum lipid profile is not associated with IPFD in healthy non-obese. Triglycerides, but not other components of lipid profile, is a promising biomarker for IPFD in individuals following acute pancreatitis.
Conclusions. The prevalence of metabolic syndrome observed among the study population was 90.6%, with a higher percentage in females than males. High triglyceride levels and high waist circumference were the main risk factors for MS in the diabetic population. PMID: 31187045 [PubMed - in process]
ConclusionsThe present data suggest that neighbourhood-related issues are associated with less severe adiposity among children with established obesity. Concerning cardiometabolic risk factors, shopping facilities were related to dyslipidemia and fatty liver. These findings suggest that increased awareness and efforts are needed to diminish socioeconomic inequalities between neighbourhoods.
This article reviews studies of the target mechanisms of herbal treatments for insulin resistance.
International Journal of Obesity, Published online: 14 June 2019; doi:10.1038/s41366-019-0399-8Radiologic evidence that hypothalamic gliosis is improved after bariatric surgery in obese women with type 2 diabetes
It has not been elucidated if an energy-restricted diet with high protein content could induce a benefit in insulin resistance in subjects with type 2 diabetes (T2DM); and if an adipose tissue functionality improvement could mediate this effect. We aimed to assess the effect of energy-restricted diets with standard (18% from total calories; SP) vs. high (35%) protein (HP), mainly coming from lean animal source, composition on glucose metabolism and adipokine concentration in overweight and obese subjects with T2DM.