Size matters: the importance of particle size in a newly developed injectable formulation for the treatment of schizophrenia.

Size matters: the importance of particle size in a newly developed injectable formulation for the treatment of schizophrenia. CNS Spectr. 2019 May 21;:1-8 Authors: Jain R, Meyer J, Wehr A, Rege B, von Moltke L, Weiden PJ Abstract One of the challenges with initiating long-acting injectable (LAI) antipsychotic regimens is achieving relevant drug levels quickly. After first injection of the LAI antipsychotic aripiprazole lauroxil (AL), the lag to reaching relevant plasma aripiprazole levels was initially addressed using supplemental oral aripiprazole for 21 days. A 1-day AL initiation regimen using a NanoCrystal® Dispersion formulation of AL (ALNCD; Aristada Initio®) combined with a single 30 mg dose of oral aripiprazole has been developed as an alternative approach. We compared the 1-day AL initiation regimen (ALNCD + 30 mg oral aripiprazole for 1 day) with the 21-day AL initiation regimen (AL + 15 mg/day of oral aripiprazole for 21 days) using kinetic modeling. Observed and modeled data demonstrate that the 1-day AL initiation regimen provides continuous aripiprazole exposure comparable to the 21-day AL initiation regimen. Each component of the 1-day AL initiation regimen (30 mg oral aripiprazole, ALNCD, and AL) contributes to aripiprazole plasma levels at different times, with oral aripiprazole predominating in the first week, then ALNCD and AL over time. In a double-blind, placebo-controlled, phase 1 study in patients with schizophrenia, the 1-...
Source: CNS Spectrums - Category: Neurology Authors: Tags: CNS Spectr Source Type: research

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Publication date: December 2019Source: Schizophrenia Research: Cognition, Volume 18Author(s): Luca Pani, Richard S.E. Keefe
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research
Publication date: Available online 15 June 2019Source: Journal of Psychiatric ResearchAuthor(s): Fan Guo, Yuan-Qiang Zhu, Chen Li, Xing-Rui Wang, Hua-Ning Wang, Wen-Ming Liu, Liu-Xian Wang, Ping Tian, Xiao-Wei Kang, Long-Biao Cui, Yi-Bin Xi, Hong YinAbstractDespite evidence of structural brain abnormalities in schizophrenia, the current study aimed to explore the effects of antipsychotic treatment on gray matter (GM) volume using structural magnetic resonance imaging (MRI) and investigate the relationship between brain structure and treatment response. The GM volumes of 33 patients with first-episode schizophrenia were cal...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
This study investigated the effects of chronic CBD treatment on markers of glutamatergic, GABAergic and endocannabinoid signalling in brain regions implicated in social behaviour and cognitive function, including the prefrontal cortex (PFC) and hippocampus (HPC). Time-mated pregnant Sprague-Dawley rats (n = 16) were administered poly I:C (4 mg/kg, i.v.) or saline (control) on gestational day 15. Male offspring were injected with CBD (10 mg/kg, i.p.) or vehicle twice daily from postnatal day 56 for 3 weeks. The prefrontal cortex (PFC) and hippocampus (HPC) were collected for post-mortem receptor binding and Wester...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Researchers at Ben-Gurion University of the Negev (BGU) and Cedars-Sinai Medical Center in Los Angeles said that for the first time they have duplicated a patient's blood-brain barrier (BBB) with stem cells. In turn, the research team said this can be used to develop personalized medicine and new techniques to research brain disorders. The new research, published in the journal Cell Stem Cell, is a collaboration between Dr. Gad Vatine of BGU's Regenerative Medicine and Stem Cell Research Center and Department of Physiology and Cell Biology and Dr. Clive N. Svendsen, of Cedars-Sinai Medical Center in Los Angeles. The BBB bl...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news
CONCLUSIONS: Modifiable predictors of supported employment outcomes included cognitive functioning and negative symptom severity; thus, interventions to improve these factors may improve work outcomes and decrease the loss of productivity associated with severe mental illness. PMID: 31185856 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
CONCLUSIONS: Half of those who died by suicide had at least one diagnosed mental health condition in the year before death, and most mental health conditions were associated with an increased risk of suicide. Findings suggest the importance of suicide screening and providing an approach to improve awareness of mental health conditions. PMID: 31185853 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
AbstractIt has been shown that dystrobrevin-binding protein 1 gene that encodes the protein dysbindin-1 is associated with risk for cognitive deficits, and studies have shown decreases in glutamate and correlated decreases in dysbindin-1 protein in the prefrontal cortex (PFC) and hippocampus of post-mortem tissue from schizophrenia patients. The PFC and the hippocampus have been shown to play a fundamental role in cognition, and studies in dysbindin-1 null mice have shown alterations in NMDAR located in pyramidal neurons as well as perturbation in LTP and cognitive deficits. The balance between excitatory and inhibitory tr...
Source: Psychopharmacology - Category: Psychiatry Source Type: research
In this study, we enrolled 110 first-episode patients with schizophrenia (FEP) and 50 healthy controls (HC). Cognitive function and psychopathology were assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) and Positive and Negative Syndrome Scale (PANSS), respectively. NMDAR antibody levels were measured using enzyme-linked immunosorbent assay. Our results showed that FEP with schizophrenia exhibited cognitive deficits in all domains of the MCCB and had elevated levels of serum anti-NMDAR antibody compared with the healthy controls (9....
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 12 June 2019Source: The LancetAuthor(s): Fiona Charlson, Mark van Ommeren, Abraham Flaxman, Joseph Cornett, Harvey Whiteford, Shekhar SaxenaSummaryBackgroundExisting WHO estimates of the prevalence of mental disorders in emergency settings are more than a decade old and do not reflect modern methods to gather existing data and derive estimates. We sought to update WHO estimates for the prevalence of mental disorders in conflict-affected settings and calculate the burden per 1000 population.MethodsIn this systematic review and meta-analysis, we updated a previous systematic review by searc...
Source: The Lancet - Category: General Medicine Source Type: research
 While searching for a way past her own childhood sexual abuse, Rachel Grant learned that many people don’t understand what, exactly, sexual abuse is and how to recover. Using her counseling background, Rachel was able to research and learn valuable coping skills to improve her own life. Join us as Gabe and Rachel discuss the many factors involved in recovering from sexual trauma, steps society could take to reduce sexual abuse, and what the first step could be for others trying to get beyond surviving. SUBSCRIBE &REVIEW   Guest information for ‘Sexual Abuse Recovery’ Podcast Episode Rachel...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Podcast Recovery The Psych Central Show Trauma Source Type: blogs
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