18F ‐N aF PET/CT IMAGING IN FIBROUS DYSPLASIA OF BONE

ABSTRACTFibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity. The purpose of this study was to investigate the utility of18F ‐NaF PET/CT imaging in quantifying disease activity in patients with FD. Fifteen consecutively evaluated subjects underwent whole‐body18F ‐NaF PET/CT scans, and FD burden was assessed by quantifying FD‐related18F ‐NaF activity.18F ‐NaF PET/CT parameters obtained included (i) SUVmax (standardized uptake value [SUV] of the FD lesion with the highest uptake); (ii) SUVmean (average SUV of all18F ‐NaF–positive FD lesions); (iii) total volume of all18F ‐NaF–positive FD lesions (TV); and (iv) total FD lesion activity determined as the product of TV multiplied by SUVmean (TA =   TV ×  SUVmean) (TA). Skeletal outcomes, functional outcomes, and bone turnover markers were correlated with18F ‐NaF PET/CT parameters. TV and TA of extracranial FD lesions correlated strongly with skeletal outcomes including fractures and surgeries (p values ≤ 0.003). Subjects with impaired ambulation and scoliosis had significantly higher TV and TA values (P<  0.05), obtained from extracranial and spinal lesions, respectively. Craniofacial surgeries correlated with TV and TA of skull FD lesions (P<  0.001). Bone turnover markers, including alkaline phosphatase, N‐telopeptid...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research