Cervical cancer in Tanzania a systematic review of current challenges in six domains

Publication date: Available online 21 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Ava Runge, Megan Bernstein, Alexa Lucas, Krishnansu S. TewariAbstractCervical cancer is the most common cancer in Tanzania. After excluding human immunodeficiency virus, lower respiratory infections, malaria, diarrheal diseases, and tuberculosis, cervical cancer kills more women than any other form of illness in the country. Unfortunately, Tanzania has a low doctor-to-patient ratio (1:50,000) and nearly 7000 women die each year from this disease. The clinical problem is further magnified by the country's lack of resources and prevailing poverty, sporadic cervical cancer screening, prevalence of high-risk oncogenic human papillomavirus subtypes, and relatively high rates of human immunodeficiency virus co-infection. In recent years, addressing the cervical cancer problem has become a priority for the Tanzanian government. In this systematic review of 39 peer-reviewed publications that appeared in the PubMed/MEDLINE (NCBI) database from 2013 to 2018, we synthesize the growing body of literature to capture current trends in Tanzania's evolving cervical cancer landscape. Six domains were identified, including risk factors, primary prevention, barriers to screening, treatment, healthcare worker education, and sustainability. In addition to traditional risk factors associated with sexual behavior, acetowhite changes observed during visual inspection of the cervix with acetic acid, lower edu...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research

Related Links:

CONCLUSION: Patients with non-cancer symptoms are frequently referred with suspected cancer. Patients with red flag symptoms are not aware of their significance and they have low expectations of healthcare. PMID: 31439066 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Jinyang Chen, Yan Wu, Cuicui Fu, Haiyan Cao, Xiaoping Tan, Wenbing Shi, Zhaoyang WuAbstractMicroRNAs (miRNAs) serve as significant regulators in a variety of diseases and have been emerging as a class of promising biomarkers for early cancer diagnosis. Herein, an enzyme-free surface-enhanced Raman scattering (SERS) platform was proposed for sensitive and reliable detection of target miRNA-21 using a corrective internal standard (IS)-based ratiometric SERS probe coupled with mismatched catalytic hairpin assembly (CHA) amplification....
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Moslem Afzali, Ali Mostafavi, Tayebeh ShamspurAbstractDespite its useful properties, imiquimod (IMQ), known as an anti-cancer drug, can be harmful to the skin at high concentrations. Therefore, we have developed a novel electrochemical sensor to determine IMQ, for the first time. A glassy carbon electrode (GCE) was modified by a new composite comprising of ionic liquid-based molecularly imprinted polymer (MIP) and gold nanoparticles/graphene oxide (Au/GO). The MIP/Au/GO nanocomposite was synthesized through non-covalent imprinting ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 23 August 2019Source: MethodsAuthor(s): Jianji Chen, Cari Sagum, Mark T BedfordAbstractSignal transduction is driven by protein interactions that are controlled by posttranslational modifications (PTM). Usually, protein domains are responsible for “reading” the PTM signal deposited on the interacting partners. Protein domain microarrays have been developed as a high throughput platform to facilitate the rapid identification of protein-protein interactions, and this approach has become broadly used in biomedical research. In this review, we will summarize the history, developme...
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Anindita De, Hari Prakash Ray, Preeti Jain, Harsimrut Kaur, Nikita SinghAbstractSchiff base ligand (E)-2-(2-hydroxy-3-methoxybenzylideneamino)acetic acid) and its Mn(II), Fe(II),Co(III),Ni (II), Cu(II) and Zn(II) complexes were synthesized and characterized by elemental analysis, UV–Vis, IR, 1H NMR, EPR and X-ray crystallography techniques. The ligand and its metal complexes were evaluated for their DNA cleavage activity using E. Coli genome by agarose gel electrophoresis method. Molecular docking studies performed for ...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 5 January 2020Source: Journal of Molecular Structure, Volume 1199Author(s): Di Wu, Liang Guo, Si-Jie LiAbstractTwo Schiff base ligands 2-((ethylamino)methyl)-6-methoxyphenol (HL1) and (E)-2-(((2-(dimethylamino)ethyl)imino)methyl)-6-methoxyphenol (HL2) with bi-nucleating or tri-nucleating mode have been successfully prepared via an one step organic condensation reaction, which were further applied in the synthesis of three new Cu(II) and Ni(II)-based coordination complexes [Cu(L1)2](EtOH) (1), [Ni(L1)2](EtOH) (2) and [Cu(L2)(HL2)(SCN)](MeOH)2 (3). Furthermore, a hand grinding technique has been used to dec...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
This study was done by collecting wild PU and cultivated PU and compared with a counterfeit which is commonly found in the market. Fourier Transform Infrared (FTIR) and Two-Dimension Infrared (2DIR) for the qualitative analysis are often regarded as green methods because the original resources of the test sample are preserved. The different spectral patterns of the counterfeit PU compared with the genuine PU were clearly indicated in 1D FTIR spectrum. The 2DIR spectrum of counterfeit PU showed more than 70% dissimilarity compared to genuine PU. This rapid and simple sample preparation enhances the speed of qualitative anal...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Yu-Ying Tian, Zhi-Guo Xin, Hai-Feng Hou, Xiao-Chun Zhu, Qian Guo, Qin XiaoAbstractTwo new Cu(II)-containing coordination complexes with the chemical formulae of [Cu2(pydc)2(H2O)2]n (1, pydc = 3,5-pyridinedicarboxylate) and {[Cu(H2O)2(H3hmidc)2](H2O)}n (2, H4hmidc = 2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylic acid) have been successfully synthesized and characterized under solvothermal conditions. The in vitro anti-tumor activities of compounds 1 and 2 were studied on human atrial myxoma cell HemECs. The WST-8 as...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study; spectroscopic, electronic and biological properties of Boc-D-Lys-OH (BDLO) molecule have been examined using quantum chemical calculations. First of all, the molecule was optimized and geometric structure parameters and vibrational wavenumbers were calculated by DFT/ B3LYP methods 6-311G++(d,p) basis set. The calculated wavenumbers were then compared with the experimental values of the FT-IR and FT-Raman spectra. Finally, the molecular docking was determined for anti apoptotic proteins with BDLO molecule. The results showed Boc-D-Lys-OH molecule had more binding affinity with AKT1 and concluded this molecule...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: August 2019Source: Gynecologic Oncology Reports, Volume 29Author(s): Ava S. Runge, Megan E. Bernstein, Alexa N. Lucas, Krishnansu S. TewariAbstractCervical cancer is the most common cancer in Tanzania. After excluding human immunodeficiency virus, lower respiratory infections, malaria, diarrheal diseases, and tuberculosis, cervical cancer kills more women than any other form of illness in the country. Unfortunately, Tanzania has a low doctor-to-patient ratio (1:50,000) and nearly 7000 women die each year from this disease. The clinical problem is further magnified by the country's lack of resources and pr...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
More News: Acetic Acid | Cancer | Cancer & Oncology | Cervical Cancer | Databases & Libraries | Education | Genital Warts | Government | Human Papillomavirus (HPV) | Malaria | OBGYN | Respiratory Medicine | Rural Health | Tanzania Health | Tuberculosis | Universities & Medical Training | Women