Stopping bDMARDs Before RA Hip, Knee Arthroplasty Questioned Stopping bDMARDs Before RA Hip, Knee Arthroplasty Questioned

Postarthroplasty infection risk in those with rheumatoid arthritis was higher after even modest preoperative doses of glucocorticoids. No difference in infection risk was detected among biologic therapies.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news

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ConclusionsThe hypoglycemic mechanism of DOP might be associated with the regulation of glucagon-mediated hepatic glycogen metabolism and gluconeogenesis, and of liver glycogen structure, contributing to improved hepatic glucose metabolism in diabetic mice.Graphical abstractDOP could regulate glucagon-mediated signaling pathways and reverse the instability of liver glycogen structure, contributing to improved hepatic glucose metabolism.
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractAryl hydrocarbon receptor (AhR), a type of transcriptional factor, is widely expressed in immune cells. The activation of AhR signaling pathway depends on its ligands, which exist in environment and can also be produced by metabolism. Normal expressions of AhR and AhR-mediated signaling may be essential for immune responses, and effects of AhR signaling on the development and function of innate and adaptive immune cells have also been revealed in previous studies. Recent studies also indicate that aberrant AhR signaling may be related to autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus eryth...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
PMID: 31610577 [PubMed - in process]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
Last year, Medgadget heard from Noble International about its “smart” training devices that educate patients on safe and effective at-home use of prefilled syringes and autoinjectors. At the time, Joe Reynolds, Research Manager at Noble I...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Pediatrics Source Type: blogs
Are respiratory viral infections associated with an increased risk for the later development of rheumatoid arthritis? A new study investigates.Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
Two JAK inhibitors, one recently approved by the FDA, have shown improvements in patients with active RA for whom other therapies have proved ineffective...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis drug treatment filgotinib Rheumatoid Arthritis (RA) upadacitinib Source Type: research
AbstractObjectivesTo study the involvement of regulatory T cells (Tregs) expressing tumor necrosis factor ‐αreceptor 2 (TNFR2) incontrol of experimental inflammation and response to treatment in rheumatoid arthritis (RA) and spondyloarthritis (SpA).MethodsThe role of TNFR2 inTregswas exploredusing amultilevel translational approach.Tregstability was evaluatedby analyzing methylation status of thefoxp3locus by bisulfite sequencing. Two models of inflammation (imiquimod ‐induced skin inflammationand delayed type hypersensitivity arthritis, DTHA) were induced inTNFR2‐deficient (TNFR2‐/‐) micewith or without tr...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research
The Pharmacogenomics Journal, Published online: 14 October 2019; doi:10.1038/s41397-019-0097-xFolyl polyglutamate synthethase (FPGS) gene polymorphisms may influence methotrexate adverse events in South Indian Tamil Rheumatoid Arthritis patients
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Any of you have any luck successfully managing a patient who argues with you that their lab results are abnormal, demanding tests that aren't indicated? I have done more of a work up than most would have done at this point and I do not think more testing is warranted. Example platelets of 180 they state is "lower end of normal, and is therefore abnormal," "a basophil percentage of 0.3% is low" and wanting rheumatoid arthritis work up with only symptom being dyspepsia. Explaining that... Dealing with difficult patients
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Family Medicine Source Type: forums
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