Discriminating schizophrenia disease progression using a P50 sensory gating task with dense-array EEG, clinical assessments, and cognitive tests.

Discriminating schizophrenia disease progression using a P50 sensory gating task with dense-array EEG, clinical assessments, and cognitive tests. Expert Rev Neurother. 2019 May;19(5):459-470 Authors: Luo Y, Zhang J, Wang C, Zhao X, Chang Q, Wang H, Wang C Abstract BACKGROUND: Schizophrenia affects approximately 10% of the world's population. Early detection of schizophrenia may significantly delay its progression. Although sensory gating deficits are reported in schizophrenia, it remains challenging how sensory gating deficits can be used with other metrics for risk detection and early diagnosis. RESEARCH DESIGN AND METHODS: Using EEG, the authors examined effects of sensory gating on the performance of 136 participants in a P50 sensory gating task, including patients with first-episode schizophrenia (FESZ), ultra-high risk (UHR) individuals, high-risk (HR) individuals, and age- and sex-matched healthy controls (HCs). The authors also explored the differences among all groups using clinical assessments and cognitive tests. RESULTS: Compared with HCs, HR, UHR and FESZ groups showed significant P50 suppression impairment. Furthermore, EEG source localization analyses identified successively stronger activation in prefrontal and anterior temporal regions in the HR, UHR and FESZ groups than in the HC group. Moreover, brain connectivity (HC 
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research

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Publication date: Available online 16 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Kazu Nakazawa, Kiran SapkotaAbstractN-methyl-D-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in autism, Alzheimer’s disease and cognitive dementia, it is crucial to identify the location, timing, and mechanism of NMDAR hypofunction for schizophrenia for better understanding of disease etiology and for novel therapeutic intervention. In this review, we first discuss the shared underlying mechanisms of NMDAR hypofunction...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Neuroscience LettersAuthor(s): László Banki, Alexandra Büki, Gyongyi Horvath, Gabriella Kekesi, Gyongyi Kis, Ferenc Somogyvári, Gábor Jancsó, Lászlo Vécsei, Endre Varga, Gabor TubolyAbstractClinical studies have shown that schizophrenia is accompanied by hypoalgesia. Accordingly, we have previously reported that a chronic schizophrenia-related rat substrain (Wisket) showed decreased acute heat pain sensitivity. The aim of the present study was to determine the mechanical pain sensitivity and the effects of opioid...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Transcranial direct current stimulation (tDCS) appears to be an effective and safe add-on treatment for ameliorating negative symptoms in schizophrenia, such as loss of interest in everyday activities and emotional withdrawal, according to astudy published yesterday inJAMA Psychiatry. This noninvasive therapy delivers weak, direct currents into the brain via electrodes placed on the scalp.“There is an unmet clinical need for the treatment of negative symptoms in schizophrenia,” wrote Leandro da Costa Lane Valiengo, M.D., Ph.D., of the Instituto Nacional de Biomarcadores em Neuropsiquiatria Faculdade de Medicina...
Source: Psychiatr News - Category: Psychiatry Tags: DSM JAMA Psychiatry Leandro da Costa Lane Valiengo negative symptoms PANSS schizophrenia tDCS Transcranial Direct Current Stimulation Source Type: research
BACKGROUND: Despite several studies on the prevalence and pattern of substance use in Nigeria, there is little information on substance use in patients diagnosed with serious mental illness (SMI) such as schizophrenia and bipolar affective disorder (BD)....
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
CONCLUSION: Any treatment targeting solely the symptoms proves to be insufficient for patients with schizophrenia. Treatment planning should focus on the needs of patients and the needs identified by patients should be at the center of the treatment. A 'needs assessment' will make an important contribution not only to the planning of individual treatments but also to the planning of a community mental health services scheme and increasing its effectiveness. PMID: 31613977 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
This study was conducted from June 2013 to December 2015. RESULTS: The proportion of patients with depressive symptoms (total score on HDRS-17 ≥ 8) in men was significantly higher than in women (male: 62.2%, female: 48.1%; χ²₁ = 4.28, P = .039). Male patients had significantly greater depressive symptoms as shown on the HDRS-17 than female patients (t1, 238 = 2.75, P = .006). Further, we found that age, the age at onset, smoking rate, and PANSS total and general psychopathology, negative symptoms, and cognitive factor subscores favored significant sex differences in female patients (all P
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSION: We confirm the emerging evidence of a decreasing long-term diagnostic stability of schizophrenia, and a protective role of female sex. The association between premorbid intelligence and symptomatic remission underscores the pertinence of including cognitive deficits in the diagnostic category of schizophrenia. The association between younger age at diagnosis and symptomatic remission may reflect positive effects of early detection or a drift in the interpretation of the diagnostic classification system. PMID: 31614250 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
ConclusionsThe limited literature showed that resilience is important in understanding suicidal thoughts and behaviours in people with schizophrenia diagnoses. There is a need for prospective research that investigates moderating effects of psychological resilience in the pathways to suicidal thoughts and behaviours in people with schizophrenia diagnoses.Practitioner pointsNovel evidence for four psychological constructs which may confer resilience to suicidal thoughts and behaviours in people with schizophrenia diagnoses.Strong evidence for the impact of perceived social support and appraisals of personal skills and attri...
Source: Psychology and Psychotherapy: Theory, Research and Practice - Category: Psychiatry & Psychology Authors: Tags: Review Article Source Type: research
Translational Psychiatry, Published online: 17 October 2019; doi:10.1038/s41398-019-0599-yAttention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
Translational Psychiatry, Published online: 17 October 2019; doi:10.1038/s41398-019-0596-1Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
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