One-year follow-up of a remotely delivered epilepsy self-management program in high-risk people with epilepsy

ConclusionsThis post-RCT extension study suggests that adults with epilepsy who participate in the SMART intervention sustain clinical effects at 1-year follow-up and may have incremental improvements in seizure frequency and mood. Future research needs to identify opportunities for scale-up and outreach to other high-risk groups with epilepsy.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Publication date: August 2019Source: Epilepsy &Behavior, Volume 97Author(s): Siqi Ding, Xueying Li, Yingjie Hua, Feirong Dong, Jiahe Lin, Yanru Du, Jingzan Shen, Niange Xia, Zhenguo Zhu, Xinshi Wang, Rongyuan Zheng, Huiqin XuAbstractObjectiveThe major cause of premature mortality in people with epilepsy (PWE) is suicide. Actual data on the risk of suicidal tendency in adult PWE in China are scarce. In our study, associations between possible risk factors and suicidal tendency in adult PWE in China were investigated.MethodsPeople with epilepsy (n = 251) were recruited, and their demographic and clinical characterist...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 22 June 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Maude Bordeleau, Micaël Carrier, Giamal N. Luheshi, Marie-Ève TremblayAbstractIn addition to their traditional role as immune sentinels, recent discoveries over the last decade have shown that microglial functions now include regulation of neuronal/glial cell migration, differentiation and maturation, as well as neuronal network formation. It was thus proposed that disruption of these microglial roles, during critical periods of brain development, could lead to the pathological onset of several neurodeve...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
The following is adapted from an excerpt from social and medical historian Katherine Foxhall’s new book, Migraine: A History, published by Johns Hopkins University Press, and out June 18, 2019. In 1936, Alfred Goltman, a physician from Tennessee, reported on one of his cases in the prominent medical journal Allergy. The patient was a 26-year-old woman with a history of headaches, nausea, and vomiting since childhood. Goltman believed the observations he had made on this patient helped reveal the pathological physiology of migraine. He had first met the woman, a registered nurse, in 1931. He recorded that for as lon...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Headache History Migraine Source Type: news
A group of drugs often prescribed for epilepsy and neuropathic pain are linked to an increased risk of suicidal behaviour, according to a study by international researchers from Sweden, the UK and the US.
Source: Nursing Times - Category: Nursing Source Type: news
Conditions:   Atrial Fibrillation;   Coronary Heart Disease;   Cardiovascular Diseases;   Heart Failure;   Hypertension;   Peripheral Arterial Disease;   Stroke, Ischemic;   Asthma;   Chronic Obstructive Pulmonary Disease;   Obesity;   Cancer;   Chronic Kidney Diseases;   Diabetes Me llitus;   Dementia;   Depression;   Epilepsy;   Mental Health Disorder;   Rheumatoid Arthritis;   Blood Pressure Intervention:   Sponsor:   Future&nbs...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The aim of this study was to evaluate in detail behavioral patterns and comorbid disturbances in rats using the lithium-pilocarpine model. A comprehensive set of behavioral tests was used to investigate behavioral patterns, including the open field test, Morris water maze, Y-maze, fear conditioning, the elevated plus maze, the forced swimming test, and the resident-intruder paradigm. Motor and explorative activity, learning and memory, anxiety and depressive-like behavior, aggression, and communication were evaluated 8-15 d after pilocarpine-induced status epilepticus (SE) (latent phase of the model) and ...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Oddo S, Kochen S Abstract Purpose: Changes in calbindin (CB) expression have been reported in patients with temporal lobe epilepsy (TLE) with controversial implications on hippocampal functions. The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits. Methods: Selected hippocampal samples from patients with TLE who underwent epilepsy surgery were included. Clinical and complementary assessment: EEG, video-EEG, MRI, psychiatric assessment (structured...
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
Abstract Anxiety and depression in children and adolescents with epilepsy are common comorbidities which place a significant burden on patients and families and complicate the clinical management of epilepsy. This paper presents a narrative review on the aetiology, phenomenology, assessment, and management of depression and anxiety among paediatric patients with epilepsy. The recognition of affective comorbidity in paediatric epilepsy is limited at present, and the contributory role of antiepileptic medication towards such comorbidity must be considered by clinicians. PMID: 31191736 [PubMed - in process]
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
ConclusionSelf-management may be effective in improving for quality of life in adult epileptics. However, these findings should be interpreted with caution due to the methodological quality of included trials. Furthermore, strict trials with precise methodological design and rigorous reporting on clinical efficacy and adverse events controlling self-management for epilepsy may be promising.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
The medicine, pregabalin (Lyrica), comes from a class of drugs called gabapentinoids.
Source: WebMD Health - Category: Consumer Health News Source Type: news
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