NF- κB/c-Rel deficiency causes Parkinson’s disease-like prodromal symptoms and progressive pathology in mice

ConclusionsIn c-rel-/- mice, reproducing a parkinsonian progressive pathology with non-motor and motor symptoms, a Braak-like pattern of brain ascending α-synuclein deposition occurs. The peculiar phenotype of c-rel-/- mice envisages a potential contribution of c-Rel dysregulation to the pathogenesis of PD.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research