Creatinine Versus Cystatin C To Estimate Glomerular Filtration Rate In Adults With Congenital Heart DiseaseResults of the Boston Adult Congenital Heart Disease Biobank

Publication date: Available online 22 May 2019Source: American Heart JournalAuthor(s): Alexander R. Opotowsky, Matthew Carazo, Michael N. Singh, Konstantinos Dimopoulos, David A. Cardona-Estrada, Ahmed Elantably, Sushrut S. Waikar, Finnian R. Mc Causland, Gruschen Veldtman, Jasmine Grewal, Catherine Gray, Brittani N. Loukas, Saurabh RajpalAbstractBackgroundGlomerular filtration rate is a key physiologic variable with a central role in clinical decision-making and a strong association with prognosis in diverse populations. Reduced estimated glomerular filtration rate (eGFR) is common among adults with congenital heart disease (ACHD).MethodsWe conducted a prospective cohort study of outpatient ACHD≥18 years-old seen 2012–2017. Creatinine and cystatin C were measured; eGFR was calculated using either the creatinine or cystatin C Chronic Kidney Disease-Epidemiology Collaboration equation (respectively: CKD-EPICr, CKD-EPICysC). Survival analysis was performed to define the relationship between eGFR and both all-cause mortality and a composite outcome of death or non-elective cardiovascular hospitalization.ResultsOur cohort included 911 ACHD (39 ± 14 years-old, 49% female). Mean CKD-EPICr and CKD-EPICysC were similar (101 ± 20 vs. 100 ± 23 mL/min/1.73m2), but CKD-EPICr estimates were higher for patients with a Fontan circulation (n = 131, +10 ± 19 mL/min/1.73m2). After mean fo...
Source: American Heart Journal - Category: Cardiology Source Type: research

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Authors: Kubota M Abstract Recent evidence suggests that hyperuricemia is an important condition in children and adolescents, particularly in association with noncommunicable diseases. This review aims to summarize our current understanding of this condition in pediatric patients. An analysis of serum uric acid reference values in a healthy population indicates that they increase gradually with age until adolescence, with differences between the sexes arising at about 12 years of age. This information should be taken into consideration when defining hyperuricemia in studies. Gout is extremely rare in childre...
Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
In conclusion, our study shows that free vitamin D serum concentrations are independently associated with major cardiovascular events in chronic kidney disease patients on dialysis.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research
CONCLUSION.: The higher the intensity of regular PA, the less likely older adults with CKD were to participate; Practitioners could consider the psychosocial characteristics of the older adults with CKD and facilitate their participation in PA. PMID: 31141443 [PubMed - as supplied by publisher]
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research
Publication date: Available online 28 May 2019Source: Canadian Journal of CardiologyAuthor(s): Julien Ternacle, Nancy Côté, Laura Krapf, Annabelle Nguyen, Marie-Annick Clavel, Philippe PibarotABSTRACTValvular heart calcification is common in patients with chronic kidney disease (CKD), especially in those receiving hemodialysis therapy, and it is associated with poor prognosis. Furthermore, progression of valvular heart disease (VHD) and structural valve deterioration of bioprosthetic valves are faster in these patients. Mechanisms involved in the pathophysiology of VHD are similar between patients with and wit...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
AbstractPurpose of ReviewDespite enhanced screening and therapeutic management, hypertension remains the most prevalent chronic disease in the United States and the leading cause of heart disease, chronic kidney disease, and stroke in both men and women. It is widely accepted that hypertension is a pro-inflammatory disease and that the immune system plays a vital role in mediating hypertensive outcomes and end organ damage. Despite known discrepancies in the risk of hypertension development between men and women, preclinical models of immune-mediated hypertension were historically developed solely in male animals, leading ...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
AbstractBackgroundStable ischemic heart disease (SIHD) is prevalent in patients with chronic kidney disease (CKD); however, whether guideline-directed medical therapy (GDMT) is adequately implemented in patients with SIHD and CKD is unknown.HypothesisUse of GDMT and achievement of treatment targets would be higher in SIHD patients without CKD than in patients with CKD.MethodsThis was a retrospective study of 563 consecutive patients with SIHD (mean age 67.8  years, 84% Caucasians, 40% females). CKD was defined as an estimated glomerular filtration rate (eGFR) of
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Redemption of Medtronic’s renal denervation program to treat hypertension is seemingly on the horizon. The Dublin-based company reported results from an investigator-led study and a registry that demonstrate long-term results of RDN’s impact on uncontrolled hypertension. These results were presented during a Late-Breaking Clinical Trial session at EuroPCR in Paris. In the investigator -led study data indicated RDN with the Medtronic Symplicity system was associated with reduced occurrence of subclinical Atrial Fibrillation (AFib) in a small subset of high-risk patients with hypertensive ...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Business Source Type: news
AbstractPurpose of the ReviewCardiorenal syndrome (CRS), defined as concomitant heart and kidney disease, has been a focus of attention for nearly a decade. As more patients survive severe acute and chronic heart and kidney diseases, CRS has emerged as an “epidemic” of modern medicine. Significant advances have been made in unraveling the complex mechanisms that underlie CRS based on classification of the condition into five pathophysiologic subtypes. In types 1 and 2, acute or chronic heart disease results in renal dysfunction, while in types 3 and 4, acute or chronic kidney diseases are the inciting factors f...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Cardiovascular disease is the leading cause of morbidity and mortality in patients with kidney disease in the United States. The risk of cardiovascular events increases with progression of kidney disease, and significant resources are spent in health care in treating kidney and cardiovascular disease disorders. The current issue of Cardiology Clinics aims to bridge the gap between the 2 specialties of nephrology and cardiology. Each article comprehensively summarizes various important concepts of heart and kidney connection, including pathophysiology and management of cardiorenal syndrome, contrast-induced nephropathy, the...
Source: Cardiology Clinics - Category: Cardiology Authors: Tags: Preface Source Type: research
Hui-Min Liu1,2, Qin Hu3, Qiang Zhang4, Guan-Yue Su5, Hong-Mei Xiao1,2, Bo-Yang Li1,2, Wen-Di Shen1,2, Xiang Qiu1,2, Wan-Qiang Lv1,2 and Hong-Wen Deng1,2,6* 1Center of System Biology and Data Information, School of Basic Medical Science, Central South University, Changsha, China 2Center of Reproductive Health, School of Basic Medical Science, Central South University, Changsha, China 3Kangda College of Nanjing Medical University, Nanjing, China 4College of Public Health, Zhengzhou University, Zhengzhou, China 5Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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