Antidepressant Use During Pregnancy and the Risk of Attention-deficit/Hyperactivity Disorder in the Children: A Meta-Analysis of Cohort Studies

(BJOG. 2018;125(9):1077–1084) Approximately 10% of pregnant women use antidepressants during pregnancy. Evidence for the relationship between antidepressant use during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) in their offspring is conflicting. ADHD is heritable yet there are environmental factors that may be involved in the development of the disorder. This was a systematic literature review and meta-analysis to assess the association between fetal exposure to antidepressant drugs and the subsequent development of ADHD.
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Epidemiologic Reports Surveys Source Type: research

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This study aims to examine the association between early gestational maternal C-reactive protein (CRP), prospectively assayed in stored maternal sera and the risk of ADHD in offspring. This study is based on the Finnish Prenatal studies of ADHD (FIPS-ADHD) with a nested case –control design. It includes all singleton-born children in Finland between January 1, 1998 and December 31, 1999 and diagnosed with ADHD. A total of 1079 cases and equal number of controls were matched on date of birth, sex and place of birth. Maternal CRP levels were assessed using a latex immun oassay from archived maternal serum specimens, co...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Conclusions/interpretationThere is evidence to suggest that in utero exposure to maternal pre-existing diabetes is associated with some adverse neurocognitive and behavioural outcomes. It remains unclear what the role of perinatal factors is and the degree to which other environmental factors contribute to these findings.
Source: Diabetologia - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewTo present current data on the coexistence of attention deficit hyperactivity disorder (ADHD) and the metabolic syndrome and type 2 diabetes mellitus in adults and children and to discuss possible mechanisms.Recent FindingsEmerging data suggest that risk factors for obesity and insulin resistance such as diabetes during pregnancy and intrauterine growth failure may also have a role in the development of ADHD. Furthermore, ADHD and obesity share lifestyle factors, such as abnormal eating patterns, binge eating, and a sedentary lifestyle. ADHD is a risk factor for components of the metabolic syndrome...
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research
Authors: Jenabi E, Bashirian S, Khazaei S, Basiri Z Abstract This meta-analysis evaluated the association between maternal pre-pregnancy body mass index (BMI) and the risk of attention deficit hyperactivity disorder (ADHD) among children and adolescents. The search strategy was conducted until December 2018 in databases of PubMed, Web of Science and Scopus. The ORs or HRs with 95% confidence intervals (CI) extracted from eligible studies used as the common measure of association among studies. A significant association was found between overweight women and risk of ADHD among children with the pooled estimates of H...
Source: Korean Journal of Pediatrics - Category: Pediatrics Tags: Korean J Pediatr Source Type: research
ABSTRACT: Objective: To assess the interaction between maternal attention-deficit/hyperactivity disorder (ADHD) history and young parental age on child's ADHD risk. Methods: The study included 321,272 singleton children born between 1995 and 2012 from hospitals within a single integrated health care organization. The children were prospectively followed up through electronic medical record systems from birth until the first date of the following: date of clinical diagnosis of ADHD, last date of continuous health plan membership, death due to any cause, or December 31, 2017. Risks of ADHD associated with a maternal h...
Source: Journal of Developmental and Behavioral Pediatrics - Category: Child Development Tags: Original Article Source Type: research
Abstract The anti-inflammatory diet is based on two diets that have been shown to have many positive health effects-the Mediterranean diet and the Okinawan diet. The anti-inflammatory diet is more than just a prescription for healthy food, but rather a way of life characterized by a plant-based diet and a pattern of living that includes eating a diverse range of locally grown foods eaten in season, conviviality, culinary activities, physical activity, and rest. The Mediterranean diet has been shown to reduce the burden and even prevent the development of cardiovascular disease, breast cancer, depression, colorecta...
Source: Pediatric Annals - Category: Pediatrics Authors: Tags: Pediatr Ann Source Type: research
ConclusionsMaternal antenatal active atopy may be a risk factor for the development of ADHD-like symptoms, especially among girls.
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
CONCLUSIONS: Maternal antenatal active atopy may be a risk factor for the development of ADHD-like symptoms, especially among girls. PMID: 31158498 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
The objective of this population-based study was to examine the association between synthetic oxytocin use during labor and hyperactivity/inattention problems in the children.
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Epidemiologic Reports Surveys Source Type: research
Conclusion: This study found that HIV-infected pubertal children showed a delayed cortical maturation with atrophy. This abnormal pattern of cortical development may be the structural basis for cognitive impairment in HIV-infected children. Introduction Acquired immune deficiency syndrome (AIDS)-related encephalopathy is one of the most serious complications of AIDS and is more common in children than in adults (1). At present, there are nearly 2 million children living with human immunodeficiency virus (HIV) in the world, almost all newly infected children are infected through mother-to-child transmission (2). Effec...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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