Modulation of Target Antigen Density Improves CAR T Cell Functionality and Persistence.

CONCLUSIONS: We demonstrate that target antigen modulation is a promising strategy to improve CD22 CAR efficacy and remission durability in patients with leukemia and lymphoma.
PMID: 31110075 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - May 19, 2019 Category: Cancer & Oncology Authors: Ramakrishna S, Highfill SL, Walsh Z, Nguyen SM, Lei H, Shern JF, Qin H, Kraft IL, Stetler-Stevenson M, Yuan CM, Hwang JD, Feng Y, Zhu Z, Dimitrov D, Shah NN, Fry T Tags: Clin Cancer Res Source Type: research