Quality of Life in Schizophrenia: A Meta-Analysis of Comparative Studies

AbstractStudies and findings regarding the impact of schizophrenia on quality of life (QOL) has been highly variable. This meta-analysis compared QOL between schizophrenia subjects and healthy controls with a focus on standardized measures. A systematic literature search was conducted through Pubmed, PsycINFO, EMBASE, Cochrane Library and Web of Science databases. Only studies using the World Health Organization Quality of Life (WHOQOL) or its brief version or the Short Form-36 Health Survey (SF-36) were included. Fifteen case-control studies with 2195 schizophrenia subjects and 1508 healthy controls were included in this meta-analysis. The WHOQOL/WHOQOL-BREF score was significantly lower in physical health (SMD  = -1.80, 95% CI: -2.31 to −1.28,P 
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research

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Publication date: Available online 24 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Jean-Christophe Debost, Janne Tidselbak Larsen, Trine Munk-Olsen, Preben Bo Mortensen, Esben Agerbo, Liselotte Vogdrup PetersenAbstractChildhood infection has been proposed as an important etiologic factor for schizophrenia. However, it is unclear to what extent the association between childhood infection and schizophrenia is confounded by parental socioeconomic status and mental illness, and childhood adversity, and whether the association is explained by familial liability for infections. We used a historical, population-based ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Could the advancement of machine and deep learning algorithms be harnessed meaningfully in the area of mental health? Could depression, bipolar disorder, schizophrenia, or any other mental disorder be quantified so that technology could somehow add positively to their diagnostics or treatment? We tried to explore the uses of artificial intelligence in mental health care, and stumbled upon smart algorithms that support clinicians with early detection and diagnostics of mental health issues, with the flagging of suicide risks, and other ones that help patients manage their condition through counselling and constantly being t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine AI artificial intelligence bipolar disorder chatbots future of psychiatry mental disorder mental health mental health disorders mental health issues moodkit pacifica schizophrenia suicide thriveport woebot Source Type: blogs
This study addressed these inconsistencies by applying latent class analysis (LCA) based on the most frequently explored variables in prior research. This novel case-centred methodology identified similarities and differences between the subjects contained in the sample instead of the variables explored. The LCA was performed on 71 variables taken from data on a previously unstudied sample of 370 case histories of offenders with SSD in a centre for inpatient forensic therapies in Switzerland. Results were compared with Hodgins' theoretically postulated patient typologies and confirm three separate homogeneous classes of sc...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
CONCLUSIONS: Our results suggest a causal role of insomnia in autism spectrum disorder and bipolar disorder. Future disease models should include insomnia as a factor for these two disorders to develop effective interventions. More detailed mechanism studies may also be inspired by this causal inference. PMID: 31234011 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
Transposable elements (TEs) are highly repetitive DNA sequences in the human genome that are the relics of previous retrotransposition events. Although the majority of TEs are transcriptionally inactive due to acquired mutations or epigenetic processes, around 8% of TEs exert transcriptional activity. It has been found that TEs contribute to somatic mosaicism that accounts for functional specification of various brain cells. Indeed, autonomous retrotransposition of long interspersed element-1 (LINE-1) sequences has been reported in the neural rat progenitor cells from the hippocampus, the human foetal brain and the human e...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 24 June 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Xinyu Fang, Yan Chen, Yewei Wang, Juanjuan Ren, Chen ZhangAbstractObjectivesDepressive symptoms are commonly seen in schizophrenia. Increasing evidence implicates that both SIRT1 and BDNF closely related to the development of depression. So we here aimed to explore the effect of BDNF and SIRT1 on the depressive symptoms, and also explore the hazard factors for the depression in schizophrenia.MethodsA group of 203 participants (case/controls, 174/29) was recruited in the present work. Significant d...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
This study reports a framework to discriminate patients with schizophrenia and normal healthy control subjects, based on magnetic resonance imaging (MRI) of the brain. Resting-state functional MRI data from a total of 144 subjects (72 patients with schizophrenia and 72 healthy controls) was obtained from a publicly available dataset using a three-dimensional convolution neural network 3D-CNN based deep learning classification framework and ICA based features.ResultsWe achieved 98.09 ± 1.01% ten-fold cross-validated classification accuracy with a p-value
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Condition:   Schizophrenia Intervention:   Other: fMRI Sponsor:   University Hospital, Caen Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Psychosis;   Schizophrenia Interventions:   Behavioral: Virtual Reality Therapy (V-NeST);   Other: Treatment as Usual Sponsor:   Institute of Psychiatry, London Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Schizophrenia;   Traumatic Brain Injury Intervention:   Other: Electroencephalography Sponsor:   VA Office of Research and Development Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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