ShcC proteins: Brain aging and beyond.

ShcC proteins: Brain aging and beyond.
Ageing Res Rev. 2014 Nov 24;
Authors: Sagi O, Budovsky A, Wolfson M, Fraifeld VE
Abstract
To date, most studies of Shc family of signaling adaptor proteins have been focused on the near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and longevity. Although the role of the neuronal ShcC protein is much less investigated, accumulated evidence suggests its importance for neuroprotection against such aging-associated conditions as brain ischemia and oxidative stress. Here, we summarize more than decade of studies on the ShcC expression and function in normal brain, age-related brain pathologies and immune disorders with a focus on the interactions of ShcC with signaling proteins/pathways, and the possible implications of these interactions for changes associated with aging.
PMID: 25462193 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - November 24, 2014 Category: Genetics & Stem Cells Authors: Sagi O, Budovsky A, Wolfson M, Fraifeld VE Tags: Ageing Res Rev Source Type: research