Chlorogenic acid prevents paraquat-induced apoptosis via Sirt1-mediated regulation of redox and mitochondrial function.

Chlorogenic acid prevents paraquat-induced apoptosis via Sirt1-mediated regulation of redox and mitochondrial function. Free Radic Res. 2019 May 20;:1-241 Authors: Kong D, Ding Y, Liu J, Liu R, Zhang J, Zhou Q, Long Z, Peng J, Li L, Bai H, Hai C Abstract Paraquat (PQ) is a widely used agro-chemical in agriculture and highly toxic to humans. Although the mechanism of PQ poisoning is not clear, it has been well documented that reactive oxygen species (ROS) generation and apoptosis play pivotal roles. Alternatively, chlorogenic acid (CA) is a biologically active dietary polyphenol, playing several therapeutic roles. However, it is not known whether CA has protective effect on PQ-induced apoptosis. Here, we investigated the effect of CA in preventing PQ-induced apoptosis and explored the underlying mechanisms. A549 cells were pretreated with 100 µM CA for 24 h and then exposed to 160 µM PQ for 24 h. We found that CA was effective in preventing PQ-induced apoptotic features, including the release of cytochrome c from the mitochondria to cytoplasm, the cleavages of caspase 3 and caspase 9, and the increases in levels of Bcl-2-associated X protein (Bax) and intracellular calcium ions. CA alleviated ROS production and prevented the reduction of antioxidant capacity in cells exposed to PQ by increasing NF-E2-related factor 2 (Nrf2), superoxide dismutase 2 (SOD2) and glutathione levels. In addition, CA also attenuated PQ-induced...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research

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CONCLUSIONS: The varied pharmacologic mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacologic effects await further study. PMID: 31205106 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 16 June 2019Source: Journal of Hazardous MaterialsAuthor(s): Savita Kaliya Perumal Veerapandian, Zhiping Ye, Jean-Marc Giraudon, Nathalie De Geyter, Rino Morent, Jean-Francois LamonierAbstractThe removal of dilute trichloroethylene (TCE) in moist air by post-plasma catalysis (PPC) using Cu-Mn mixed oxides heated at 150 °C was investigated. Cu-Mn mixed oxides were prepared by redox- and co-precipitation method. In comparison to the catalytic oxidation and non-thermal plasma (NTP) process, PPC was found to be the best process to convert TCE into CO2, in particular when Cu-Mn oxid...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
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Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
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Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
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Source: Marine Chemistry - Category: Chemistry Source Type: research
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Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: Journal of Mass Spectrometry - Category: Chemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
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