Longitudinal field studies reveal early infection and persistence of influenza A virus in piglets despite the presence of maternally derived antibodies

AbstractA longitudinal study was performed in three Danish farrow to grower (30 kilos) herds over a 4-month period to investigate the dynamics and clinical impacts of influenza A virus (IAV) infections. In each herd, four batches consisting of four sows each with five ear-tagged piglets were included. Nasal swabs and/or blood were sampled from the sows and/or the piglets prior to farrowing and at weeks 1, 3, and 5 and at the end of the nursery period. Clinical examinations were performed at each sampling time. The sows and piglets were tested for IAV and IAV antibodies in nasal swabs and blood samples, respectively. The results revealed three enzootically infected herds, where the majority of the pigs were infected during the first 5  weeks after birth. Infected piglets of only 3 days of age were detected in the farrowing unit, where the sows were also shedding virus. In all herds, low to moderate numbers of infected pigs (ranging from 3.6 to 20.7%) were found to be virus positive in nasal swabs at two consecutive sampling tim es. Furthermore, clinical signs of respiratory disease were associated with IAV detection. The findings of this study documented that IAV can persist in herds and that piglets as young as 3 days can be infected despite the presence of maternally derived antibodies.
Source: Veterinary Research - Category: Veterinary Research Source Type: research

Related Links:

Date: Tuesday, 11 19, 2019; Speaker: Ian A. Wilson, D.Phil., D.Sc., Hanson Professor of Structural Biology , The Scripps Research Institute; Building: Building 10 (Clinical Center); Lipsett Amphitheater; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Results expected by end of 2020 JERUSALEM, Nov. 18, 2019 -- (Healthcare Sales &Marketing Network) -- BiondVax Pharmaceuticals Ltd. (Nasdaq: BVXV) announced today that enrollment and randomization of 12,463 participants in the pivotal, clinical efficac... Biopharmaceuticals BiondVax Pharmaceuticals, influenza vaccine
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.9b00644
Source: Bioconjugate Chemistry - Category: Biochemistry Authors: Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Yu-Qing He, Liang Cai, Qun-Gang Qian, Sheng-Hui Yang, Di-Lu Chen, Bi-Qing Zhao, Zhen-Ping Zhong, Xiao-Jiang ZhouAbstractTwo new sesquiterpenes, named carpabrotalactone A (1) and B (2), together with six known sesquiterpenes, 11(13)-dehydroivaxillin (3), eriolin (4), 2α,5α-dihydroxy-11αH-eudesma-4(15)-en-12,8β-olide (5), (5α)-5-hydroxyasperilin (6), 1α,4α-dihydroxy-guaia-11(13)-ene-12,8α-olide (7) and 4α,5α-dihydroxy-guaia-11(13)-en-12,8α-lactone (8), were isolated from the herb...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
(CNN) — The US Centers for Disease Control and Prevention told doctors on a conference call this week that the United States is seeing more flu than is typical for this time of year. “Influenza is off to an early start,” said Dr. William Schaffner, an infectious disease expert at Vanderbilt University who was on the CDC call, which included members of the Influenza Hospitalization Surveillance Network, a group of hospitals that help the CDC assess the severity of the flu season. Thirty states are seeing flu activity — for this time of year, that’s the most states in a decade. Three s...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Seen On WBZ-TV Syndicated CBSN Boston flu season Source Type: news
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
Condition:   Influenza Intervention:   Drug: Flumist Quadrivalent Nasal Product Sponsor:   University of Alabama at Birmingham Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractNo studies evaluating the association between statins and outcomes of patients with seasonal influenza have been performed since the 2007 –2008 and the 2009 pandemic H1N1 influenza seasons. All consecutive hospitalized patients between October 2017 and April 2018, diagnosed with laboratory-confirmed influenza A and B virus, were included. Patients were divided into two groups: statin and non-statin users. Outcomes were 30- and 90-da y mortality, complications (pneumonia, myocarditis, encephalitis, intensive care unit (ICU) transfer, mechanical ventilation, vasopressor support), length of hospital stay, and re...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
(Yale University) A high-fat, low-carbohydrate diet like the Keto regimen has its fans, but influenza apparently isn't one of them.Mice fed a ketogenic diet were better able to combat the flu virus than mice fed food high in carbohydrates, according to a new Yale University study published Nov. 15 in the journal Science Immunology.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
More News: Denmark Health | Influenza | Nursing | Respiratory Medicine | Study | Veterinary Research