Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis [Microbiology]

Mycobacterium tuberculosis (Mtb) killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses imposed by the immune system and tolerate exposure to antibiotics, resulting in persistent infection. The global tuberculosis (TB) epidemic has been exacerbated by the emergence of mutant strains...

Source: Proceedings of the National Academy of Sciences - May 20, 2019 Category: Science Authors: Kelly Flentie, Gregory A. Harrison, Hasan Tukenmez, Jonathan Livny, James A. D. Good, Souvik Sarkar, Dennis X. Zhu, Rachel L. Kinsella, Leslie A. Weiss, Samantha D. Solomon, Miranda E. Schene, Mette R. Hansen, Andrew G. Cairns, Martina Kulen, Torbȷ Tags: PNAS Plus Source Type: research