Stilbene Glycoside Oligomers from the Roots of Polygonum multiflorum.

Stilbene Glycoside Oligomers from the Roots of Polygonum multiflorum. Chem Biodivers. 2019 May 20;: Authors: Li SG, Huang XJ, Zhong YL, Li MM, Li YL, Wang Y, Ye WC Abstract Five new trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-D-glucopyranoside (TSG)-based stilbene glycoside oligomers (1-5) were isolated from the roots of Polygonum multiflorum. Their structures were elucidated by comprehensive spectroscopic analyses and chemical evidences. The absolute configurations of 1, 2, 4, and 5 were established by quantum-chemical electronic circular dichroism (ECD) calculations. Putative biosynthetic pathways of 1-5 were proposed using TSG as the key precursor. In addition, compounds 1 and 3 exhibited moderate inhibitory activities against NO production in LPS-stimulated RAW264.7 cells. PMID: 31107589 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research