The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans

ConclusionEvaluating the biodistribution of89Zr-AlbudAb in healthy volunteers using a low radioactivity dose was successful (total subject exposure ~  10 mSv). Results indicated rapid formation of reversible, but stable, complexes between AlbudAb and albumin upon dosing.89Zr-AlbudAb demonstrated albumin-like pharmacokinetics, including limited renal elimination. This novel organ-specific distribution data for AlbudAbs in humans will facilitate a better selection of drug targets to prosecute using the AlbudAb platform and significantly contribute to modeling work optimizing dosing of therapeutic AlbudAbs in the clinic.
Source: EJNMMI Research - Category: Radiology Source Type: research