Sequence similarity searches for morphine biosynthesis enzymes in bacteria yield putative targets for understanding associations between infection and opiate administration.

Sequence similarity searches for morphine biosynthesis enzymes in bacteria yield putative targets for understanding associations between infection and opiate administration. J Med Microbiol. 2019 May 20;: Authors: Zhan SH, French L Abstract Exploiting the immunosuppressive, analgesic and highly addictive properties of morphine could increase the success of a bacterial pathogen. Therefore, we performed sequence similarity searches for two morphine biosynthesis demethylases in bacteria. For thebaine 6-O-demethylase and codeine O-demethylase, we found strong alignments to three (Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii) of the six ESKAPE pathogens (Enterococcus faecalis, Staphylococcus aureus, K. pneumoniae, A. baumannii, P. aeruginosa and Enterobacter species) that are commonly associated with drug resistance and nosocomial infections. Expression of the aligned sequence found in P. aeruginosa (NP_252880.1/PA4191) is upregulated in isolates obtained from cystic fibrosis patients. Our findings provide putative mechanistic targets for understanding the role of morphine in pathogenicity. PMID: 31107204 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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DiscussionIn years 2011 and 2012 when the surgeries captured in this retrospective study were done, rhBMP-2 was indicated for single level (L4–S1) anterior lumbar spine fusion as a substitute for autogenous bone graft in adults with DDD. The most common procedure for the treatment with rhBMP-2 was PLF (off-label use), followed by ALIF (on-label use). The safety findings confirm a predictable and manageable safety profile.Level of evidenceIV.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
This study examined whether conscientiousness mediated and teacher support moderated the relation of parenting styles to Internet addiction in Chinese adolescents. Data were drawn from a cross-sectional study involving 1783 students aged 11 to18 years from Henan, China. Structural equation modeling (SEM) indicated that parenting styles were indirectly related to Internet addiction through conscientiousness. Further, teacher support moderated the relationship between parental refusal and Internet addiction. Specifically, the positive association of parental refusal with Internet addiction was significant for adolescents wit...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
Publication date: Available online 16 July 2019Source: Computers in Human BehaviorAuthor(s): Daniel L. King, Paul H. Delfabbro, Sally M. Gainsbury, Michael Dreier, Nancy Greer, Joel BillieuxABSTRACTVideo games as a consumer product have changed significantly with the advent of in-game purchasing systems (e.g., microtransactions, ‘loot boxes’). This review examines consumer protections related to in-game purchasing by anticipating some of the potential design strategies that might contribute to higher risk consumer behavior. Attention was directed towards the analysis of patents for potential in-game purchasing ...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
Publication date: Available online 17 July 2019Source: Microbial PathogenesisAuthor(s): K. Vinod Kumar, Archana Pal, Pooja Bai, Andeep Kour, Sheeba E, Rajarajan P, Arbiya Kausar, Monami Chatterjee, Guru Prasad, Swati Balayan, Panchatapa Dutta, Kavinda WijesekeraAbstractHuman hands play a prominent role in the intra and interpersonal transmission of microbes that constantly connect one's microbiome to other individuals and the environment. Along with beneficial bacteria, an individual may harbor pathogenic organisms which may get transferred to others. Thus, understanding the transmission mechanism and interaction among mic...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsAntibiotic consumption was lower when the antibiotic advisor was a pharmacist and when the pharmaceutical team reviewed all prescriptions. These results highlight that actions initiated by pharmacists have a positive impact and should be supported.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 July 2019Source: American Journal of Infection ControlAuthor(s): Shanice Cheatham, Dipendra Thapaliya, Mohammed Taha, Katherine Milliken, Mark R. Dalman, Jhalka Kadariya, Dylan Grenier, Tara C. SmithBackgroundMethicillin-resistant Staphylococcus aureus (MRSA) is common in medical institutions. We sought to examine the prevalence of S aureus on environmental surfaces in nursing homes and to obtain molecular information on contaminating strains.MethodsA total of 259 environmental samples were collected from 7 different nursing homes in Northeast Ohio (NEO), from suburban, urban, and rura...
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 July 2019Source: The Lancet HaematologyAuthor(s): Anne-Sophie Michallet, Marie-Sarah Dilhuydy, Fabien Subtil, Valerie Rouille, Beatrice Mahe, Kamel Laribi, Bruno Villemagne, Gilles Salles, Olivier Tournilhac, Alain Delmer, Christelle Portois, Brigitte Pegourie, Veronique Leblond, Cecile Tomowiak, Sophie de Guibert, Frederique Orsini, Anne Banos, Philippe Carassou, Guillaume Cartron, Luc Mathieu ForneckerSummaryBackgroundIn patients with chronic lymphocytic leukaemia, achievement of a complete response with minimal residual disease of less than 0·01% (ie,
Source: The Lancet Haematology - Category: Hematology Source Type: research
After some promising early indicators, preliminary federal data suggest the number of Americans who died from drug overdoses finally fell in 2018, after years of significant increases. Provisional data from the U.S. Centers for Disease Control and Prevention’s National Center for Health Statistics predicted that 68,500 Americans died of drug overdoses in 2018, compared to about 72,000 the year before. That translates to an approximately 5% reduction in overdose deaths nationwide—a small but significant step toward curbing the deadly effects of the nation’s substance abuse crisis. Opioids, as in years past...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
The criminal trial of five French telecom executives for allegedly creating psychologically stressful conditions that caused 19 worker suicides provides a stark contrast to America's lack of protection for workers from health endangering psychological harm in the workplace.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Federal data shows drug companies distributed 8.4 billion opioid pills to pharmacies from 2006 to 2012, a 50% jump
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
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