Medical News Today: How long will a person with stage 4 colon cancer live?

The 5-year relative survival rate for stage 4 colon cancer is 14%. Many factors determine the life expectancy of a person with this condition. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Colorectal Cancer Source Type: news

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Conclusions: Our findings suggest that adenine inhibits the growth of colon cancer cells. Anticancer activity of adenine in colon cancer cells is attributable to the activation of apoptotic signaling and in turn the AMPK/mTOR pathway. Adenine represents a natural compound with anticancer potency. PMID: 31611925 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 15 October 2019Source: Life SciencesAuthor(s): Xiao Yang, Yao-tun Zheng, Wei RongAbstractAimsTo investigate the effects of sevoflurane on proliferation, cell cycle, apoptosis, autophagy, invasion and epithelial-mesenchymal transition of colon cancer cell line SW480, and to explore its possible mechanism.Materials and methodsSW480 and SW620 cells were treated with a mixture of 95% O2+5% CO2 containing different concentrations of sevoflurane (1.7% SAV, 3.4% SAV and 5.1% SAV) for 6 h. Meanwhile, we performed a rescue experiment by treating cells with the ERK pathway activator LM22B-10 pr...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 12 October 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Nanasaheb D. Thorat, Joanna Bauer, Syed A.M. Tofail, Victoria Gascón Pérez, Raghvendra A. Bohara, Hemraj M. YadavAbstractCancer cells become resistant over the period to chemotherapeutic drugs and pose a challenging impediment for oncologists in providing effective treatment. Nanomedicine allows to overcome chemoresistance and is the focus of our investigation. Silica nanostructures have been highlighted as an interesting drug delivery platform in vitro and in vivo applications. Here we show the validity...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
In conclusion, adult weight gain was associated with increased risk of several major cancers. The degree, timing, and duration of overweight and obesity also seemed to be important. Preventing weight gain may reduce the cancer risk. Link:
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone. Oncotarget. 2019 Sep 24;10(54):5576-5591 Authors: Krishnamachary B, Subramaniam D, Dandawate P, Ponnurangam S, Srinivasan P, Ramamoorthy P, Umar S, Thomas SM, Dhar A, Septer S, Weir SJ, Attard T, Anant S Abstract Given that colon cancer is the third most common cancer in incidence and cause of death in the United States, and current treatment modalities are insufficient, there is a need to develop novel agents. Towards this, here we focus on γ-Mangostin, a bioactive compound present in the Mangosteen (Garcinia mangostan...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
AbstractClinical significance of the pT4 category in colon cancer is increasing with several therapeutic implications. The aim of this study was to evaluate variability in diagnosing pT4a colon cancer. Twelve pathologists classified 66 preselected scanned Hematoxylin/Eosin-stained slides with tumor cells at a distance of 25 –1500 μm (n = 22), 0–25 μm (n = 22), or on (n = 22) the peritoneal surface.Inter- andintraobserver variability were calculated using Kappa statistics. Forinterlaboratory variability, pathology reports of pT3 and pT4a colon cancer were...
Source: Virchows Archiv - Category: Pathology Source Type: research
In this study, we aimed to identify independent predictive factors for lymph node metastasis (LNM) in T1 colon cancer.MethodsData of 8056 eligible patients were retrospectively collected from the Surveillance, Epidemiology, and End Results (SEER) database during 2004 –2012. We performed logistic regression analysis to identify predictive factors for LNM. Both unadjusted and adjusted Cox regression analyses were used to determine the association between LNM and patient survival. Finally, we used competing risks analysis and the cumulative incidence function (CI F) to further confirm the prognostic role of LNM in cance...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionTo optimize targeting and visualization of the surgical field in right pelvic sidewall/paracolic gutter, robotic arms can be placed in a straight line from above the pubic symphysis extending to the left subcostal line and between the midline vertical and midclavicular lines. Robotic tumor debulking should be considered in selected patients with recurrent ovarian cancer who present with oligo-metastatic disease, in the absence of carcinomatosis.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionUniversal OpSalp during hysterectomy, BTL and elective surgery will significantly reduce OvCa mortality and reduce overall healthcare expenditures due to prevention of OvCa. Therefore, it would be reasonable to perform OpSalp in all women undergoing elective surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionSacrospinous ligament suspension for the correction of massive vaginal vault prolapse utilizing PEEK anchors and porcine urinary bladder extracellular matrix is a reasonable alternative to transvaginal synthetic mesh repairs.Advantages to this vaginal approach include: 1) Avoidance of laparoscopic risks in a patient with massive ascites, 2) Avoidance of chronic pain, erosion and extrusion associated with synthetic mesh.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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