Posterior subthalamic area deep brain stimulation for treatment of tremor and dystonia in Wilson ’s disease

Wilson ’s disease (WD) is an autosomal recessive disorder of copper metabolism associated with ATP7B gene mutations. In this condition, copper accumulates in various tissues especially the brain, and liver. The resulting cellular dysfunction commonly manifests as ataxia, tremor, dystonia and parkinsonism . Whilst copper chelation therapies, including trientene and penicillamine, are well-established disease-modifying treatments, up to 50% of patients have persistent neurological symptoms despite optimal non-surgical therapy [1].

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 20, 2019 Category: Neurology Authors: Hu Liang Low, Sian K. Alexander, Anjum Misbahuddin, Godfrey T. Gillett Source Type: research