Topological features of rugged fitness landscapes in sequence space.

Topological features of rugged fitness landscapes in sequence space.
Trends Genet. 2014 Oct 15;
Authors: Kondrashov DA, Kondrashov FA
Abstract
The factors that determine the tempo and mode of protein evolution continue to be a central question in molecular evolution. Traditionally, studies of protein evolution focused on the rates of amino acid substitutions. More recently, with the availability of sequence data and advanced experimental techniques, the focus of attention has shifted toward the study of evolutionary trajectories and the overall layout of protein fitness landscapes. In this review we describe the effect of epistasis on the topology of evolutionary pathways that are likely to be found in fitness landscapes and develop a simple theory to connect the number of maladapted genotypes to the topology of fitness landscapes with epistatic interactions. Finally, we review recent studies that have probed the extent of epistatic interactions and have begun to chart the fitness landscapes in protein sequence space.
PMID: 25438718 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - October 15, 2014 Category: Genetics & Stem Cells Authors: Kondrashov DA, Kondrashov FA Tags: Trends Genet Source Type: research