Better fit of codon usage of the polymerase and nucleoprotein genes to the chicken host for H7N9 than H9N2 AIVs

Recently, the evolution of H7N9 AIVs has been widely studied in this journal.1, 2 The six internal genes (PB2, PB1, PA, NP, M, and NS) of H7N9 are from chicken H9N2 avian influenza viruses.3 Genotypic analysis of these six internal genes revealed that the most frequent genotypes of H9N2 genotypes did not become the major genotypes in H7N9, thus it appears that H7N9 prefer some genotypes for these genes.4 The cause for this preference remains unknown, as is whether this preference helped H7N9 become a successful AIV subtype.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research