Effect of glucosamine sulfate on intraocular pressure in patients with knee osteoarthritis: A prospective randomized controlled trial.

CONCLUSIONS: Glucosamine sulfate is still an option without significant concern over elevated IOP in patients with osteoarthritis of the knee and normal ocular pressure. PMID: 31104873 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

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Authors: Oba R, Isomura M, Igarashi A, Nagata K Abstract Extracellular vesicles (EVs) are known to contain unique proteins that reflect the cells of origins. Activated T cells are reported to secrete various EVs. To establish T cell subset-specific biomarkers, we performed proteomic analysis with Th1- and Th2-derived EVs and identified HLA-DR as a Th1-dominated EV membrane protein. We designed a measurement system for CD3+CD4+, CD3+CD8+, and CD3+HLA-DR+ EVs to specifically determine EV subpopulations derived from CD4+, CD8+, and Th1-type T cells, respectively. In vitro analysis showed that CD3+CD4+ EVs and CD3+CD8+...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
BACKGROUND: A growing clinical interest has been shown towards identifying knee osteoarthritis (OA) patients at earlier stages. The early detection of knee OA may allow for more effective interventions. RESEARCH QUESTION: The aim of this study was to deter...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: Available online 18 June 2019Source: European Journal of RadiologyAuthor(s): Camille Roux, Frédérique Gandjbakhch, Audrey Pierreisnard, Marion Couderc, Cédric Lukas, Racha Masri, Jean-Philippe Sommier, Isabelle Clerc-UrmeS, Cédric Baumann, Isabelle Chary-Valckenaere, Damien LoeuilleAbstractObjectiveto determine thresholds and better scenario for the diagnosis of erosive rheumatoid arthritis (RA) by ultrasonography (US) in RA in comparison to osteoarthritic (OA) patients.MethodsPatients, prospectively included, fulfilling ACR 1987; ACR/EULAR 2010 criteria for RA or hand OA crite...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conditions:   Degenerative Arthritis;   Knee Osteoarthritis Interventions:   Biological: JOINTSTEM;   Drug: saline Sponsor:   R-Bio Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Unity Biotechnology is the furthest ahead of the growing number of young biotech companies working on senolytic therapies that can selectively destroy harmful senescent cells in aged tissues. The company has already started human trials for osteoarthritis of the knee, using local rather than systemic administration of a small molecule senolytic drug. Other companies in the space, such as Oisin Biotechnologies, will be starting in on human trials for their approaches soon. As noted here, Unity Biotechnology recently announced results from their trial. The accumulation of senescent cells throughout the body over the y...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(Duke University Medical Center) About a million times a year, Americans with a torn meniscus in their knee undergo surgery in hopes of a repair. Certain tears can't be fixed or won't heal well, and many patients later suffer osteoarthritis. To improve meniscus healing, Duke scientists have developed a scaffold derived from a pig's meniscus, which performed better in lab tests than healing without a scaffold.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Cornell University) A new type of treatment for osteoarthritis, currently in canine clinical trials, shows promise for eventual use in humans. The treatment, developed by Cornell University biomedical engineers, is a synthetic version of a naturally occurring joint lubricant that binds to the surface of cartilage in joints and acts as a cushion during high-impact activities, such as running.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
CONCLUSIONS: These results show an active role of the circadian clock in general, and of CRY2 in particular, in maintaining ECM homeostasis in cartilage. This cell autonomous network of circadian rhythm genes is disrupted in OA chondrocytes. Targeting CRY2 has potential to correct abnormal gene expression patterns and reduce the severity of OA.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
ConclusionsRobotic-assisted medial and lateral UKAs demonstrated satisfactory clinical outcomes and excellent survivorship at 3-year follow-up. Continued patient follow-up is needed to determine the long-term device performance and clinical satisfaction.Level of evidenceRetrospective cohort study, Level IV.
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Journal of Orthopaedic&Sports Physical Therapy, Ahead of Print.
Source: The Journal of Orthopaedic and Sports Physical Therapy - Category: Physiotherapy Authors: Source Type: research
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