Bone scan index as metastatic bone disease quantifier and predictor of radium-223-dichloride biochemical response
Conclusion BSI is a useful asset in stratification of patients with metastatic bone disease. It may also have a place in prediction of biochemical response.
Conclusion: The biopsy protocol that included six end-fire anterior cores did not detect more cancer and was associated with more complications. PMID: 31204873 [PubMed - as supplied by publisher]
Conclusions: PCa patients with MSCC have a poor prognosis. Most likely reflecting differences in tumor burden, preserved gait function following radiotherapy is associated with better prognosis. Further prospective studies are required to confirm this association. PMID: 31204549 [PubMed - as supplied by publisher]
ConclusionTracer biodistribution was not significantly impacted by normal tissue expression of PSCA. [89Zr]A2cDb immuno-PET yielded high tumor-to-blood ratio at early time points. Rapid renal clearance of the 50 kDa tracer resulted in an unobstructed view of the pelvic region at 20 h postinjection that would allow the detection of cancer in the prostate.
ConclusionsRadium-223 was generally well tolerated and there were no safety concerns. The adverseevents were mild and manageable. A decline in serum alkaline phosphatase was more frequent than a decline in the prostate-specific antigen. Monitoring changes in serum alkaline phosphatase dynamics may be useful.ResumenEl dicloruro de Ra223 es un radiofármaco emisor alfa que prolonga la supervivencia global en pacientes con cáncer de próstata resistente a la castración y metástasis óseas sintomáticas. Presentamos un análisis retrospectivo de 68 pacientes tratados.Mé...
Conclusions: Early assessment of PSA after surgery is important for predicting radiographic progression in node-positive prostate cancer patients. Risk stratification based on the early PSA value after surgery would be helpful to identify patients who may benefit from early adjuvant therapies.
The purpose of this study was to evaluate the imaging properties of hepatic metastases in 68Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC).
Researchers are investigating if men could benefit from a one-off scan to check their risk of prostate cancer.
The magnetic resonance imaging (MRI) scan has already been offered to 450 men in UK, with another 350 set to be screened in London this summer as part of University College trial.
Simple scans ‘could revolutionise the way that we diagnose disease’, says professorHundreds of men will be given MRI scans in a groundbreaking clinical trial that scientists say could transform screening for prostate cancer.The £5m trial, which begins in August, is pioneering a simple, 10-minute scan that scientists hope could provide the first reliable method for identifying dangerous tumours in the general population.Continue reading...
Objectives The aims of this study were to assess the discriminative performance of quantitative multiparametric magnetic resonance imaging (mpMRI) between prostate cancer and noncancer tissues and between tumor grade groups (GGs) in a multicenter, single-vendor study, and to investigate to what extent site-specific differences affect variations in mpMRI parameters. Materials and Methods Fifty patients with biopsy-proven prostate cancer from 5 institutions underwent a standardized preoperative mpMRI protocol. Based on the evaluation of whole-mount histopathology sections, regions of interest were placed on axial T2-wei...