Literature review of the evidence regarding intravenous lipid administration in drug-induced cardiotoxicity.

Literature review of the evidence regarding intravenous lipid administration in drug-induced cardiotoxicity. Expert Rev Clin Pharmacol. 2019 May 18;: Authors: Paneta M, Waring WS Abstract Introduction Intravenous lipid emulsion (ILE) administration is capable of reversing the acute cardiac and neurological toxicity caused by local anaesthetic agents. In recent years, ILE has also been explored as a potential antidote for cardiotoxicity caused by non-anaesthetic agents too. Areas covered The potential mechanisms, safety and efficacy of this approach are considered. Data were sought from published reports listed in PubMed and EMBASE, and abstracts of meetings of the North American Congress of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists. There were reports involving 298 patients where ILE has been administered for severe drug toxicity. Clinical improvement was observed in 57 of 59 patients with local anaesthetic toxicity (96.6%); there were 239 patients where toxicity was due to non-anaesthetic agents, and ILE apparently improved clinical outcome in 215 (72.1%). Expert opinion Response rates were similar between ILE treated toxicity caused by lipid soluble and non-lipid soluble drugs. Potential adverse effects of ILE include interference with laboratory assays, acute pancreatitis, and adult respiratory distress syndrome, although the rate of occurrence is difficult to ascertain. PMI...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research