The risk of emerging new psychoactive substances: The first fatal 3-MeO-PCP intoxication in The Netherlands

We present the first fatal case in the Netherlands and one of the few worldwide. Postmortem biological samples and the presumed abused unknown substance, sold as ant poison, were obtained. 3-MeO-PCP was detected, and the resulting concentration was 152 μg/l in whole blood. The presumed taken unknown sample was identified as 3-MeO-PCP and thus linked to the victim. The cause of death was a combination of 3-MeO-PCP, amphetamine, and alcohol. Improved diagnostic skills are necessary to face these emerging novel psychoactive substances also in light of public health and social risks.
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research

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CONCLUSIONS: Findings demonstrate significant heterogeneity with a core workforce supported by a range of non-core and indirect actors. Identifying characteristics and needs of the workforce supports coordinated capacity building to implement effective injury prevention and safety promotion initiatives. With this being the first review of the workforce in WA, this paper highlights the need to more regularly audit the sector to determine its breadth and composition. This article is protected by copyright. All rights reserved. PMID: 31216381 [PubMed - as supplied by publisher]
Source: Health Promotion Journal of Australia - Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research
Geneticist who unlocked the secrets of hereditary cancersIn 1962 a medical intern sat with a man recovering from alcohol poisoning in a veterans ’ hospital in the US state of Nebraska. Henry Lynch, who has died aged 91, listened as the young farm worker told him that he liked to drown his sorrows because, as with everyone else in his family, he was pretty much guaranteed to die young of cancer.Lynch, with a background in genetics and psychology, wanted to know more about this family and its high prevalence of cancer. His investigations intothis and other such families led to the discovery of hereditary non-polyposis ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Biology People in science Cancer research Medical research Medicine Education Source Type: news
BACKGROUND: Acetaminophen, the ubiquitous over-the-counter analgesic and antipyretic, is the most common drug used in intentional overdoses in the United States. Inadvertent self-poisoning is also a surprisingly common unintended consequence of acetaminoph...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
A rapid, sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination and quantification of 12 psychotropic drugs and metabolites in hair was developed and validated. After freeze grinding with methanol, the supernatant ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
This study investigated whether alcohol influences the predictive value of initial blood lactate concentration and Glasgow Coma Scale (GCS) score at presentation for the severity of acute carbon monoxide (CO) poisoning and neurologic out...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Carbon monoxide (CO) toxicity should be considered in patients presenting to the emergency department with any acute vague manifestations after hookah smoking; furthermore, smoking in an open space does not eliminate the risk of CO toxicity. High-flow supp...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Abstract Fomepizole is used as an antidote to treat methanol poisoning due to its selectivity towards alcohol dehydrogenase. In the present study, the goal is to develop a method to predict the fomepizole human plasma concentration versus time profile based on the preclinical pharmacokinetics using the assumption of superimposability on simulated time course profiles of animals and humans. Standard allometric equations with/without correction factors were also assimilated in the prediction. The volume of distribution at steady state (Vss) predicted by simple allometry (57.55 L) was very close to the reported ...
Source: AAPS PharmSciTech - Category: Drugs & Pharmacology Authors: Tags: AAPS PharmSciTech Source Type: research
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Source: Clinical Toxicology - Category: Toxicology Authors: Source Type: research
ConclusionsThe extract showed anti-ulcer potential and is ready for clinical evaluation.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Recent research has implicated economic insecurity in increasing midlife death rates and "deaths of despair," including suicide, chronic liver disease, and drug and alcohol poisoning. In this ecological longitudinal study, we evaluated the association betw...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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