"Hepatic toxicity by methotrexate with weekly single doses associated with folic acid in rheumatoid and psoriatic arthritis. What is its real frequency?"

CONCLUSIONS: No biochemical or significant histological liver toxicity for MTX was demonstrated when applying causality criteria for DILI. More studies with this methodology are necessary in order to improve the assessment of its frequency. PMID: 31105018 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research

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The pharmaceutical giant will offer Popit ’s pill detection device to rheumatoid arthritis patients.
Source: mobihealthnews - Category: Information Technology Source Type: news
If you or someone close to you have an autoimmune condition such as rheumatoid arthritis, lupus, Hashimoto’s thyroiditis, Crohn’s disease or ulcerative colitis, along with about 195 others, there are a number of steps you can take that reduce, even eliminate the autoimmune inflammation damaging your organs. (Unfortunately, some forms of autoimmune damage cannot be reversed. Autoimmune loss of pancreatic beta cells that lead to type 1 diabetes, Hashimoto’s thyroiditis that damages the thyroid gland, or autoimmune hepatitis that can lead to cirrhosis. for example, cannot be reversed even if the autoimmune p...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Autoimmunity autoimmune casein Gliadin grain-free omega-3 undoctored vitamin D wheat belly Source Type: blogs
CONCLUSIONS: Combining BTX-A injections for sialorrhea with multilevel intramuscular BTX-A injections (with or without alcohol) appears to be safe and effective and allows treatment of patients for both conditions simultaneously. PMID: 31227667 [PubMed - as supplied by publisher]
Source: Journal of Pediatric Rehabilitation Medicine - Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research
Authors: Taghadosi M, Samimi Z, Assar S, Salahshoor MR, Jalili C Abstract Background: The effect of obesity on disease severity in rheumatoid arthritis (RA) remains controversial. Adipocytes secrete pro-inflammatory cytokines and adipokines which may contribute to RA disease activity. The goal of the present study is to address the association between body mass index (BMI) with plasma levels of leptin, pro-inflammatory cytokines, and RA disease severity. Methods: Fifty RA patients (20 newly diagnosed and 30 under treatment) as well as 30 age- and sex-matched healthy subjects were included in this survey. The plasma...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
This study examines patterns and correlates of e-cigarette use frequency in a novel national sample. Methods: Data were from 36,277 US adults interviewed between 2012 and 2013 for the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III). Sociodemographic characteristics, other tobacco/drug use, and psychiatric disorders were compared by e-cigarette use status (i.e. current [past-month], past, never) and e-cigarette use frequency (i.e. infrequent [≤3 days/month], moderate [1-6 days/week], daily). Multinomial logistic regression models compared correlates of e-cigarette use...
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusion: The concomitant use of nicotine and areca indicates that betel quid addiction includes a significant component of nicotine dependence. However, the additional activities of areca, including the muscarinic effects of arecoline, indicate that potential cessation therapies should optimally address other factors as well. PMID: 31220988 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusions: Findings underscore the critical role of acculturation and alcohol-related problems in cannabis use frequency and have relevant implications for preventive efforts addressing cannabis use among Latinas at risk of an AEP. PMID: 31220980 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
The ailment worsens with age, but about 300,000 American kids also have juvenile arthritis.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Tens of thousands of Instagram followers can't be wrong: Curiosity about the sober life is trending. Scientists say cutting out alcohol can improve your sleep and blood pressure, and help your liver.(Image credit: Julia Robinson for NPR)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
In a population-based study of patients with the inflammatory disorders psoriasis and psoriatic arthritis, Ogdie and colleagues uncovered an elevated risk for new liver disease diagnosis (both non-alcoholic fatty liver disease and cirrhosis) even after adjustment for gender, body mass index, alcohol intake, and smoking. Patients with psoriasis who were treated with systemic therapy had greater risk of liver disease. Patients with psoriasis and psoriatic arthritis also had higher risk of liver disease than patients with rheumatoid arthritis, another inflammatory disease, independent of systemic therapy.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
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