Differential metabolism of imidacloprid and dinotefuran by Bemisia tabaci CYP6CM1 variants

Publication date: Available online 20 May 2019Source: Pesticide Biochemistry and PhysiologyAuthor(s): Akira Hamada, Gregory D. Wahl, Alexandre Nesterov, Toshifumi Nakao, Miyuki Kawashima, Shinichi BanbaAbstractImidacloprid has been used to control one of most serious pests, Bemisia tabaci. However, B. tabaci has developed imidacloprid resistance mainly by over-expressing CYP6CM1. It was reported that imidacloprid-resistant B. tabaci showed no or low level of cross-resistance against dinotefuran. Here, we expressed CYP6CM1 variants using Sf9/baculovirus and/or Drosophila S2 cells and showed that CYP6CM1 variants metabolized imidacloprid but not dinotefuran. In addition, we demonstrated that imidacloprid and pymetrozine competed for a CYP6CM1 variant more efficiently than dinotefuran, using a luminescent substrate competition assay. These results suggest that lack of metabolic activity of CYP6CM1 variants against dinotefuran caused no or low level of cross-resistance.Graphical abstract
Source: Pesticide Biochemistry and Physiology - Category: Biochemistry Source Type: research