Title: Analysis of hexafluoropropylene oxide-dimer acid (HFPO-DA) by Liquid Chromatography-Mass Spectrometry (LC-MS): Review of Current Approaches and Environmental Levels

Publication date: Available online 20 May 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Lauren Mullin, David Katz, Nicole Riddell, Robert Plumb, Jennifer A. Burgess, Leo W.Y. Yeung, Ingrid Ericson JogstenAbstractEmerging per- and polyfluorinated compounds (PFAS) compounds are of increasing interest for environmental monitoring, one being hexafluoropropylene oxide-dimer acid (HFPO-DA), commonly referred to as GenX. The following review describes existing liquid chromatography-mass spectrometry (LC-MS) methods used to analyze HFPO-DA, including sample preparation and method sensitivity relative to other PFAS. Analytical challenges are also described, in particular the significant formation of in-source fragmentation, dimer and dimer adducts which detract from [M-H]- signal. Lastly, detected levels of HFPO-DA in environmental and biological samples are compared across the limited number of available field exposure studies, which found several μg/L concentrations in water samples taken near fluorochemical plant discharges.
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research