Immobilization of boron-rich compound on Fe3O4 nanoparticles: Stability and cytotoxicity

Publication date: 15 August 2019Source: Journal of Alloys and Compounds, Volume 797Author(s): D.I. Tishkevich, I.V. Korolkov, A.L. Kozlovskiy, M. Anisovich, D.A. Vinnik, A.E. Ermekova, A.I. Vorobjova, E.E. Shumskaya, T.I. Zubar, S.V. Trukhanov, M.V. Zdorovets, A.V. TrukhanovAbstractMagnetic nanoparticles based on Fe3O4 and their modifications of surface with therapeutic substances are of great interest, especially drug delivery for cancer therapy includes boron-neutron capture therapy. The results of boron-rich compound (carborane borate) attachment to previously aminated by (3-aminopropyl)-trimethoxysilane iron oxide nanoparticles are presented. Energy-dispersive X-ray analysis and Fourier transform infrared spectroscopy with attenuated total reflection (ATR) accessory confirmed change of nanoparticles elemental content after modification and formation of new bond between Fe3O4 and attached molecules. Scanning and transmission electron microscopy showed that Fe3O4 nanoparticles average size is 18.9 nm. Phase parameters were investigated by powder X-ray diffraction, Fe3O4 nanoparticles magnetic behavior was evaluated by Mössbauer spectroscopy. Chemical and colloidal stability was studied using simulated body fluid (phosphate buffer – PBS). Modified nanoparticles have excellent stability in PBS (pH = 7.4), characterized by X-ray diffraction, Mössbauer spectroscopy and dynamic light scattering. Fe3O4 biocompatibility was elucidated in-vitro using cultured ...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research

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