A Case of Gitelman's Syndrome that was difficult to distinguish from Hypokalemic Periodic Paralysis due to Graves' Disease.

A Case of Gitelman's Syndrome that was difficult to distinguish from Hypokalemic Periodic Paralysis due to Graves' Disease. J Nippon Med Sch. 2019 May 17;: Authors: Oba T, Kobayashi S, Nakamura Y, Nagao M, Nozu K, Fukuda I, Iijima K, Sugihara H Abstract A 21-year-old man presented with hyperthyroidism and hypokalemia and was treated for thyrotoxic hypokalemic periodic paralysis (THPP) due to Graves' disease. Thyroid function soon normalized, but hypokalemia persisted. Laboratory data revealed hyperreninemic hyperaldosteronism and metabolic alkalosis consistent with Gitelman's Syndrome (GS). He was found to have a previously unreported compound heterozygous mutation of T180K and L858H in the SLC12A3 gene and was diagnosed with GS. He was started on eplerenone to control serum potassium levels. It is important to consider other diagnoses when electrolyte imbalances persist despite resolving disease. PMID: 31105122 [PubMed - as supplied by publisher]
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research

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